Spg11 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spg11
SPG11, spatacsin vesicle trafficking associated
MGI:2444989

26 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spg11^em1(IMPC)J/Spg11^em1(IMPC)J C57BL/6NJ-Spg11^em1(IMPC)J/Mmjax	decreased circulating calcium level	J:211773
	decreased circulating total protein level	J:211773
	decreased exploration in new environment	J:211773
	decreased heart rate	J:211773
	increased leukocyte cell number	J:211773
	increased startle reflex	J:211773
	increased total body fat amount	J:211773
	prolonged RR interval	J:211773
Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} involves: 129P2/OlaHsd * C57BL/6	abnormal autophagy	J:228803
	abnormal corticospinal tract morphology	J:228803
	abnormal gait	J:228803
	abnormal hippocampus pyramidal cell morphology	J:228803
	abnormal lysosome morphology	J:228803
	abnormal lysosome physiology	J:228803
	abnormal neuron morphology	J:228803
	abnormal Purkinje cell morphology	J:228803
	astrocytosis	J:228803
	ataxia	J:228803
	axon degeneration	J:228803
	brain atrophy	J:228803
	decreased brain weight	J:228803
	impaired coordination	J:228803
	motor neuron degeneration	J:228803
	neuron degeneration	J:228803
	Purkinje cell degeneration	J:228803
	weight loss	J:228803

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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