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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mavs
mitochondrial antiviral signaling protein
MGI:2444773
38 phenotypes from 4 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Mavstm1Aki/Mavstm1Aki
involves: 129P2/OlaHsd * C57BL/6
decreased CD8-positive, alpha-beta T cell number J:130954
decreased circulating interferon-alpha level J:130954
decreased circulating interferon-beta level J:130954
decreased circulating interferon-gamma level J:130954
decreased circulating interleukin-6 level J:130954
decreased IgG1 level J:130954
decreased IgG2a level J:130954
decreased IgG level J:130954
decreased interferon-beta secretion J:130954
decreased interleukin-12b secretion J:130954
Mavstm1Aki/Mavstm1Aki
involves: 129S/SvEv * C57BL/6
abnormal circulating interferon level J:162888
abnormal dendritic cell physiology J:162888
abnormal macrophage physiology J:162888
abnormal neuron physiology J:162888
brain inflammation J:162888
CNS inflammation J:162888
decreased CD4-positive, alpha beta T cell number J:162888
decreased CD8-positive, alpha-beta T cell number J:162888
decreased interferon-beta secretion J:162888
enlarged spleen J:162888
normal immune system phenotype J:162888
increased circulating interferon-gamma level J:162888
increased circulating interleukin-6 level J:162888
increased circulating tumor necrosis factor level J:162888
increased dendritic cell number J:162888
increased IgG2a level J:162888
increased IgG level J:162888
increased IgM level J:162888
increased susceptibility to viral infection J:162888
increased susceptibility to viral infection induced morbidity/mortality J:162888
neuron degeneration J:162888
Mavstm1Aki/Mavstm1Aki
involves: C57BL/6
normal immune system phenotype J:132662
Mavstm1Aki/Mavstm1Aki
Not Specified
abnormal cytokine secretion J:124405
abnormal response to infection J:124405
decreased circulating interleukin-6 level J:124405
decreased interferon-alpha secretion J:124405
decreased interferon-beta secretion J:124405
decreased interleukin-6 secretion J:124405
increased susceptibility to viral infection J:124405
Mavstm1Camb/Mavstm1Camb
involves: 129S6/SvEvTac * C57BL/6
abnormal B cell physiology J:180356
decreased B cell proliferation J:180356
decreased interleukin-12 secretion J:180356
decreased tumor necrosis factor secretion J:180356
Mavstm1Tsc/Mavstm1Tsc
Not Specified
decreased interferon-beta secretion J:136289
Mavstm1Zjc/Mavs+
involves: 129/Sv * C57BL/6
abnormal innate immunity J:110905
increased susceptibility to viral infection J:110905
Mavstm1Zjc/Mavstm1Zjc
B6.Cg-Mavstm1Zjc
abnormal circulating interferon level J:243916
Mavstm1Zjc/Mavstm1Zjc
involves: 129/Sv * C57BL/6
abnormal dendritic cell physiology J:110905
abnormal innate immunity J:110905
abnormal macrophage physiology J:110905
increased susceptibility to viral infection J:110905

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory