Plekhm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plekhm1
pleckstrin homology domain containing, family M (with RUN domain) member 1
MGI:2443207

23 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ctsk^tm1(cre)Ska/Ctsk⁺ Plekhm1^tm1.1Hzhao/Plekhm1^tm1.1Hzhao involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal lysosome morphology	J:236517
	abnormal osteoclast morphology	J:236517
	abnormal osteoclast physiology	J:236517
	decreased bone mineralization	J:236517
	decreased bone ossification	J:236517
	decreased bone resorption	J:236517
	decreased bone trabecular spacing	J:236517
	decreased lysosomal enzyme secretion	J:236517
	decreased osteoblast cell number	J:236517
	increased bone trabecula number	J:236517
	increased trabecular bone mass	J:236517
	increased trabecular bone volume	J:236517
Plekhm1^{Gt(OST201689)Lex}/Plekhm1^{Gt(OST201689)Lex} B6;129S5-Plekhm1^{Gt(OST201689)Lex}/Orl	no abnormal phenotype detected	J:82809
Plekhm1^tm1.2Hzhao/Plekhm1^tm1.2Hzhao involves: 129S1/Sv * C57BL/6J	abnormal lysosome morphology	J:236517
	abnormal osteoclast morphology	J:236517
	abnormal osteoclast physiology	J:236517
	decreased bone mineralization	J:236517
	decreased bone ossification	J:236517
	decreased bone resorption	J:236517
	decreased bone trabecular spacing	J:236517
	decreased lysosomal enzyme secretion	J:236517
	decreased osteoblast cell number	J:236517
	increased bone trabecula number	J:236517
	increased trabecular bone mass	J:236517
	increased trabecular bone volume	J:236517
Plekhm1^{tm1b(EUCOMM)Hmgu}/Plekhm1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Plekhm1^{tm1b(EUCOMM)Hmgu}/Tcp	abnormal optic disk morphology	J:211773
	abnormal vertebrae morphology	J:211773
	decreased prepulse inhibition	J:211773
	decreased total body fat amount	J:211773
	increased bone mineral content	J:211773
	increased bone mineral density	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	polycystic kidney	J:211773
	short tibia	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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