Dusp4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dusp4
dual specificity phosphatase 4
MGI:2442191

25 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dusp4^Gt(XG164)Byg/Dusp4^Gt(XG164)Byg B6.129P2-Dusp4^Gt(XG164)Byg	normal immune system phenotype	J:180366
	increased CD4-positive, alpha-beta T cell number	J:180366
	increased interleukin-10 secretion	J:180366
	increased T cell proliferation	J:180366
Dusp4^{tm1a(EUCOMM)Wtsi}/Dusp4^{tm1a(EUCOMM)Wtsi} C57BL/6N-Dusp4^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased caudal vertebrae number	J:175295
	decreased circulating glucose level	J:175295
	decreased circulating potassium level	J:175295
	decreased circulating sodium level	J:175295
	decreased lumbar vertebrae number	J:175295
	decreased rib number	J:175295
	decreased thoracic vertebrae number	J:175295
	increased circulating sodium level	J:175295
	increased sacral vertebrae number	J:175295
Dusp4^tm1Jmol/Dusp4^tm1Jmol involves: 129	decreased B cell apoptosis	J:140567
Dusp4^tm1Plev/Dusp4^tm1Plev involves: 129/Sv * C57BL/6	abnormal macrophage physiology	J:170774
	decreased IgG2a level	J:170774
	decreased interferon-gamma secretion	J:170774
	decreased interleukin-10 secretion	J:170774
	increased IgG1 level	J:170774
	increased interleukin-4 secretion	J:170774
	increased interleukin-6 secretion	J:170774
	increased interleukin-12 secretion	J:170774
	increased interleukin-13 secretion	J:170774
	increased susceptibility to parasitic infection	J:170774
	increased tumor necrosis factor secretion	J:170774

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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