Tox Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tox
thymocyte selection-associated high mobility group box
MGI:2181659

28 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Tox)1Kay/? Tox^tm1.1Kay/Tox^tm1.1Kay involves: 129S6/SvEvTac * C57BL/6	abnormal T cell number	J:131287
Tox^tm1.1Kay/Tox^tm1.1Kay involves: 129S6/SvEvTac	abnormal CD4-positive T cell differentiation	J:131287
	abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology	J:131287
	abnormal CD8-positive, alpha beta T cell morphology	J:131287
	decreased CD4-positive, alpha-beta T cell number	J:131287
	decreased cytotoxic T cell cytolysis	J:131287
	decreased NK T cell number	J:131287
Tox^tm1.1Kay/Tox^tm1.1Kay involves: 129S6/SvEvTac * C57BL/6	abnormal positive T cell selection	J:164687
	abnormal small intestine morphology	J:164687
	abnormal spleen morphology	J:164687
	absent axillary lymph nodes	J:164687
	absent inguinal lymph nodes	J:164687
	absent mesenteric lymph nodes	J:164687
	absent popliteal lymph nodes	J:164687
	decreased NK cell number	J:164687
	decreased Peyer's patch number	J:164687
	small Peyer's patches	J:164687
Tox^{tm1b(KOMP)Wtsi}/Tox^{tm1b(KOMP)Wtsi} C57BL/6N-Tox^{tm1b(KOMP)Wtsi}/Tcp	abnormal auditory brainstem response	J:211773
	abnormal heart morphology	J:211773
	abnormal startle reflex	J:211773
	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased circulating cholesterol level	J:211773
	decreased prepulse inhibition	J:211773
	enlarged heart	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased spleen weight	J:211773
	prolonged RR interval	J:211773
Tox^tm1Kay/Tox^tm1Kay Tg(Lck-cre)1Cwi/0 involves: 129S6/SvEvTac * C57BL/6	abnormal CD4-positive T cell differentiation	J:164687

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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