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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ticam1
TIR domain containing adaptor molecule 1
MGI:2147032
63 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ticam1Lps2/Ticam1Lps2
C57BL/6J-Ticam1Lps2 		abnormal circulating tumor necrosis factor level J:138963
abnormal cytokine secretion J:167340
abnormal enterocyte physiology J:167340
abnormal postnatal growth/weight/body size J:167340
abnormal retina progenitor cell morphology J:141070
decreased interleukin-6 secretion J:167340
decreased susceptibility to alcohol-induced hepatic steatosis J:138963
decreased susceptibility to induced colitis J:167340
normal immune system phenotype J:131353
normal nervous system phenotype J:155613
Ticam1Lps2/Ticam1Lps2
C57BL/6J-Ticam1Lps2/J 		abnormal chemokine level J:288471
abnormal forced expiratory flow rates J:288471
abnormal respiratory function J:288471
decreased CD8-positive, alpha-beta T cell number J:288471
decreased Ly6C low monocyte number J:288471
decreased susceptibility to injury J:193668
increased airway responsiveness J:288471
increased interferon-beta secretion J:288471
increased Ly6C high monocyte number J:288471
increased macrophage cell number J:288471
increased neutrophil cell number J:288471
increased plasmacytoid dendritic cell number J:288471
increased susceptibility to Coronaviridae infection J:288471
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:288471
lung hemorrhage J:288471
Ticam1Lps2/Ticam1Lps2
involves: C57BL/6 		abnormal cytokine secretion J:110201
abnormal macrophage physiology J:84896
decreased circulating tumor necrosis factor level J:86521
decreased macrophage apoptosis J:84896, J:92674
decreased macrophage cytokine production J:84896
decreased macrophage nitric oxide production J:84896
decreased susceptibility to bacterial infection J:86521, J:92674
decreased susceptibility to endotoxin shock J:84896
decreased tumor necrosis factor secretion J:84896
increased susceptibility to Herpesvirales infection J:84896
Ticam1M2Btlr/Ticam1+
C57BL/6J-Ticam1M2Btlr 		abnormal cytokine secretion J:234240
abnormal macrophage physiology J:234240
decreased macrophage cytokine production J:234240
decreased tumor necrosis factor secretion J:234240
Ticam1M2Btlr/Ticam1M2Btlr
C57BL/6J-Ticam1M2Btlr 		abnormal cytokine secretion J:234240
abnormal macrophage physiology J:234240
decreased macrophage cytokine production J:234240
decreased tumor necrosis factor secretion J:234240
Ticam1M3Btlr/Ticam1+
C57BL/6J-Ticam1M3Btlr 		decreased tumor necrosis factor secretion J:255300
Ticam1M3Btlr/Ticam1M3Btlr
C57BL/6J-Ticam1M3Btlr 		decreased tumor necrosis factor secretion J:255300
Ticam1tm1Aki/Ticam1tm1Aki
B6.129P2-Ticam1tm1Aki 		abnormal cytokine level J:144301
abnormal response to infection J:144301
decreased circulating tumor necrosis factor level J:144301
decreased macrophage cytokine production J:144301
impaired neutrophil recruitment J:144301
increased susceptibility to bacterial infection J:144301
Ticam1tm1Aki/Ticam1tm1Aki
involves: 129P2/OlaHsd 		abnormal B cell activation J:174941
abnormal B cell physiology J:84679
abnormal cytokine level J:174941
abnormal cytokine secretion J:84679
abnormal dendritic cell physiology J:174941
abnormal interleukin level J:137522
abnormal macrophage physiology J:84679, J:174941
abnormal microglial cell physiology J:185198
abnormal NK cell physiology J:174941
abnormal NK T cell physiology J:174941
decreased circulating interleukin-6 level J:145306
decreased splenocyte proliferation J:84679
decreased susceptibility to endotoxin shock J:84679
decreased susceptibility to injury J:145306
decreased susceptibility to Orthomyxoviridae infection J:145306
impaired macrophage phagocytosis J:185198
Ticam1tm1Aki/Ticam1tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal cytokine level J:169158
abnormal susceptibility to Poxviridae infection J:162716
decreased CD8-positive, alpha-beta T cell number J:130954
decreased circulating interferon-gamma level J:130954
decreased circulating interleukin-6 level J:130954
decreased circulating interleukin-12b level J:130954
decreased IgG2a level J:130954
decreased IgG level J:130954
decreased interferon-beta secretion J:130954
decreased interleukin-12b secretion J:130954
decreased susceptibility to type I hypersensitivity reaction J:161445
decreased susceptibility to weight loss J:162716
normal immune system phenotype J:132662
increased susceptibility to Picornaviridae infection J:169158
increased susceptibility to Picornaviridae infection induced morbidity/mortality J:169158
myocarditis J:169158
Ticam1tm1Tsse/Ticam1tm1Tsse
B6.129-Ticam1tm1Tsse 		impaired natural killer cell mediated cytotoxicity J:118750
increased tumor growth/size J:118750
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory