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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Pcsk9
proprotein convertase subtilisin/kexin type 9
MGI:2140260
12 phenotypes from 7 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Pcsk9m1Bms/Pcsk9+
B6.Cg-Pcsk9m1Bms
decreased circulating LDL cholesterol level J:200728
Pcsk9m1Bms/Pcsk9m1Bms
B6.Cg-Pcsk9m1Bms
decreased circulating LDL cholesterol level J:200728
increased bile salt level J:200728
Pcsk9tm1.1Prat/Pcsk9tm1.1Prat
Speer6-ps1Tg(Alb-cre)21Mgn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
decreased circulating cholesterol level J:169834
decreased circulating HDL cholesterol level J:169834
decreased circulating LDL cholesterol level J:169834
Pcsk9tm1.2Prat/Pcsk9tm1.2Prat
involves: 129S1/Sv * 129X1/SvJ
abnormal cholesterol homeostasis J:169834
abnormal liver regeneration J:169834
decreased circulating cholesterol level J:169834
decreased circulating HDL cholesterol level J:169834
decreased circulating LDL cholesterol level J:169834
decreased liver regeneration J:169834
Pcsk9tm1Jdh/Pcsk9tm1Jdh
involves: 129S6/SvEvTac
decreased circulating cholesterol level J:97836
decreased circulating HDL cholesterol level J:97836
decreased circulating LDL cholesterol level J:97836
Pcsk9tm2b(EUCOMM)Hmgu/Pcsk9tm2b(EUCOMM)Hmgu
C57BL/6N-Pcsk9tm2b(EUCOMM)Hmgu/Ieg
decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
increased circulating alkaline phosphatase level J:211773
Tg(Apoe-Pcsk9)#Prat/?
involves: C3H * C57BL/6
increased circulating cholesterol level J:169834
increased circulating HDL cholesterol level J:169834
increased circulating LDL cholesterol level J:169834
Tg(Apoe-Pcsk9*H229A)#Prat/?
involves: C3H * C57BL/6
normal homeostasis/metabolism phenotype J:169834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory