Rps6kb2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rps6kb2
ribosomal protein S6 kinase, polypeptide 2
MGI:1927343

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho Rps6kb2^tm1Gtho/Rps6kb2⁺ involves: 129P2/OlaHsd * C57BL/6	postnatal lethality, incomplete penetrance	J:89696
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho Rps6kb2^tm1Gtho/Rps6kb2^tm1Gtho B6.129P2-Rps6kb1^tm1Gtho Rps6kb2^tm1Gtho	neonatal lethality, incomplete penetrance	J:89696
	perinatal lethality, incomplete penetrance	J:89696
	postnatal growth retardation	J:89696
	postnatal lethality, incomplete penetrance	J:89696
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho Rps6kb2^tm1Gtho/Rps6kb2^tm1Gtho involves: 129P2/OlaHsd	abnormal cellular respiration	J:129852
	abnormal lipid level	J:129852
	abnormal mitochondrial morphology	J:129852
	abnormal muscle physiology	J:129852
	abnormal skeletal muscle morphology	J:129852
	decreased skeletal muscle fiber diameter	J:129852
	increased fatty acid beta-oxidation	J:129852
	increased skeletal muscle glycogen level	J:129852
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho Rps6kb2^tm1Gtho/Rps6kb2^tm1Gtho involves: 129P2/OlaHsd * C57BL/6	abnormal blood circulation	J:89696
	abnormal heart morphology	J:89696
	cyanosis	J:89696
	decreased litter size	J:89696
	hemorrhage	J:89696
	hypoxia	J:89696
	neonatal lethality, incomplete penetrance	J:89696
	perinatal lethality, incomplete penetrance	J:89696
	postnatal growth retardation	J:89696
	postnatal lethality, incomplete penetrance	J:89696
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho Rps6kb2^tm1Gtho/Rps6kb2^tm1Gtho Tg(Ins2-Akt1)3Mbb/0 involves: 129P2/OlaHsd C57BL/6 * SJL	abnormal pancreatic beta cell morphology	J:144599
	normal neoplasm	J:144599
Rps6kb2^tm1Gtho/Rps6kb2^tm1Gtho Tg(Ins2-Akt1)3Mbb/0 B6.Cg-Rps6kb2^tm1Gtho Tg(Ins2-Akt1)3Mbb	increased insulinoma incidence	J:144599

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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