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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nckap1l
NCK associated protein 1 like
MGI:1926063
57 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nckap1lm1Btlr/Nckap1lm1Btlr
C57BL/6J-Nckap1lm1Btlr
decreased alpha-beta T cell number J:272079
decreased B cell number J:272079
decreased body weight J:272079
decreased CD4-positive, alpha beta T cell number J:272079
decreased CD8-positive, alpha-beta T cell number J:272079
decreased CD8-positive, naive alpha-beta T cell number J:272079
decreased central memory CD8 positive, alpha-beta T cell number J:272079
decreased NK cell number J:272079
increased alpha-beta T cell number J:272079
increased CD8-positive, alpha-beta T cell number J:272079
increased effector memory CD4-positive, alpha-beta T cell number J:272079
increased effector memory CD8-positive, alpha-beta T cell number J:272079
Nckap1lm1Iri/Nckap1lm1Iri
involves: C57BL/6
abnormal CD4-positive T cell differentiation J:141377
abnormal common myeloid progenitor cell morphology J:141377
abnormal epididymis morphology J:141377
abnormal erythroid progenitor cell morphology J:141377
abnormal immune system organ morphology J:141377
abnormal liver morphology J:141377
abnormal lymphopoiesis J:141377
abnormal regulatory T cell number J:141377
abnormal renal glomerulus morphology J:141377
abnormal thoracic cavity morphology J:141377
abnormal thymus lobule morphology J:141377
acanthocytosis J:141377
amyloidosis J:141377
cardiac fibrosis J:141377
dacryocytosis J:141377
decreased CD4-positive, alpha beta T cell number J:141377
decreased CD8-positive, alpha-beta T cell number J:141377
decreased double-positive T cell number J:141377
decreased hematocrit J:141377
decreased lymphocyte cell number J:141377
decreased mature B cell number J:141377
decreased mature gamma-delta T cell number J:141377
decreased mean corpuscular volume J:141377
decreased T cell proliferation J:141377
extramedullary hematopoiesis J:141377
heart inflammation J:141377
hypochromic microcytic anemia J:141377
impaired macrophage phagocytosis J:141377
impaired neutrophil chemotaxis J:141377
impaired neutrophil phagocytosis J:141377
increased circulating interleukin-6 level J:141377
increased circulating interleukin-17 level J:141377
increased double-negative T cell number J:141377
increased erythrocyte osmotic fragility J:141377
increased interleukin-6 secretion J:141377
increased interleukin-17 secretion J:141377
increased leukocyte cell number J:141377
increased neutrophil cell number J:141377
increased tumor necrosis factor secretion J:141377
liver inflammation J:141377
lung inflammation J:141377
lymph node hypoplasia J:141377
poikilocytosis J:141377
reticulocytosis J:141377
schistocytosis J:141377
spleen hyperplasia J:141377
thymus hypoplasia J:141377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory