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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wnk4
WNK lysine deficient protein kinase 4
MGI:1917097
39 phenotypes from 7 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
involves: C3H * C57BL/6 		abnormal distal convoluted tubule morphology J:113094
normal cardiovascular system phenotype J:113094
decreased circulating chloride level J:113094
decreased circulating magnesium level J:113094
decreased circulating potassium level J:113094
decreased systemic arterial diastolic blood pressure J:113094
decreased systemic arterial systolic blood pressure J:113094
decreased urine calcium level J:113094
Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
involves: C3H * C57BL/6 		abnormal distal convoluted tubule morphology J:113094
abnormal kidney physiology J:113094
normal cardiovascular system phenotype J:113094
decreased circulating bicarbonate level J:113094
hyperkalemia J:113094
increased circulating chloride level J:113094
increased circulating magnesium level J:113094
increased systemic arterial diastolic blood pressure J:113094
increased systemic arterial systolic blood pressure J:113094
increased urine calcium level J:113094
premature death J:113094
Wnk4em1Cjc/Wnk4em1Cjc
Not Specified 		abnormal carbon dioxide level J:274218
abnormal urine sodium level J:274218
decreased circulating bicarbonate level J:274218
decreased urine potassium level J:274218
hyperkalemia J:274218
hypertension J:274218
increased circulating chloride level J:274218
increased circulating potassium level J:274218
increased urine potassium level J:274218
increased urine sodium level J:274218
metabolic acidosis J:274218
Wnk4tm1Pfi/Wnk4tm1Pfi
involves: 129S6/SvEvTac * C57BL/6J 		abnormal blood homeostasis J:184790
abnormal renal/urinary system physiology J:184790
abnormal urine homeostasis J:184790
alkalosis J:184790
normal cardiovascular system phenotype J:184790
decreased circulating aldosterone level J:184790
decreased circulating chloride level J:184790
decreased circulating magnesium level J:184790
decreased physiological sensitivity to xenobiotic J:184790
normal homeostasis/metabolism phenotype J:184790
hypokalemia J:184790
increased circulating renin level J:184790
increased urine chloride ion level J:184790
increased urine potassium level J:184790
increased urine sodium level J:184790
polyuria J:184790
Wnk4tm1Suc/Wnk4+
involves: 129S4/SvJae * C57BL/6 		acidosis J:129716
decreased circulating bicarbonate level J:129716
decreased urine potassium level J:129716
hypertension J:129716
increased circulating potassium level J:129716
Wnk4tm2.1Suc/Wnk4tm2.1Suc
involves: 129S4/SvJae * C57BL/6 		decreased systemic arterial systolic blood pressure J:152915
increased urine potassium level J:152915
increased urine sodium level J:152915
Wnk4tm3.1Suc/Wnk4tm3.1Suc
involves: 129S4/SvJae * C57BL/6J 		alkalemia J:241978
decreased circulating chloride level J:241978
decreased circulating sodium level J:241978
decreased systemic arterial systolic blood pressure J:241978
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory