Chmp2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chmp2b
charged multivesicular body protein 2B
MGI:1916192

26 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chmp2b^em1(IMPC)Mbp/Chmp2b⁺ C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/MbpMmucd	no spontaneous movement	J:211773
Chmp2b^em1(IMPC)Mbp/Chmp2b⁺ C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/Mmucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal uterus morphology	J:211773
	absent seminal vesicle	J:211773
	blind uterus	J:211773
	decreased heart rate	J:211773
	enlarged seminal vesicle	J:211773
	enlarged spleen	J:211773
	prolonged RR interval	J:211773
	small kidney	J:211773
	small testis	J:211773
Chmp2b^em1(IMPC)Mbp/Chmp2b^em1(IMPC)Mbp C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/MbpMmucd	no spontaneous movement	J:211773
Chmp2b^em1(IMPC)Mbp/Chmp2b^em1(IMPC)Mbp C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/Mmucd	preweaning lethality, incomplete penetrance	J:211773
Chmp2b^Gt(XL952)Byg/Chmp2b^Gt(XL952)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal dendritic spine morphology	J:219860
	abnormal hippocampus CA1 region morphology	J:219860
	abnormal synapse morphology	J:219860
Chmp2b^tm1.1Hiok/Chmp2b⁺ involves: C57BL/6J	abnormal cell cycle checkpoint function	J:308471
	abnormal cerebral cortex morphology	J:308471
	abnormal endoplasmic reticulum morphology	J:308471
	abnormal frontal lobe morphology	J:308471
	abnormal primary motor cortex morphology	J:308471
	cellular necrosis	J:308471
	impaired spatial learning	J:308471
	increased anxiety-related response	J:308471

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23