Nsmce2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nsmce2
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
MGI:1915751

33 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nsmce2^em1(IMPC)Bay/Nsmce2⁺ C57BL/6N-Nsmce2^em1(IMPC)Bay/Bay	abnormal embryo size	J:211773
	abnormal embryo turning	J:211773
	embryonic growth retardation	J:211773
Nsmce2^em1(IMPC)Bay/Nsmce2^em1(IMPC)Bay C57BL/6N-Nsmce2^em1(IMPC)Bay/Bay	abnormal embryo size	J:211773
	abnormal embryo turning	J:211773
	abnormal forebrain development	J:211773
	abnormal neural tube closure	J:211773
	abnormal pharyngeal arch morphology	J:211773
	abnormal visceral yolk sac morphology	J:211773
	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Nsmce2^{Gt(AA0032)Wtsi}/Nsmce2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal cell nucleus morphology	J:227197
	abnormal mitosis	J:227197
	elevated level of mitotic sister chromatid exchange	J:227197
	increased cardiovascular system tumor incidence	J:227197
	increased cell nucleus count	J:227197
	increased histiocytic sarcoma incidence	J:227197
	increased liver tumor incidence	J:227197
	increased lymphoma incidence	J:227197
	increased pancreas tumor incidence	J:227197
	increased tumor incidence	J:227197
	premature death	J:227197
Nsmce2^{Gt(AA0032)Wtsi}/Nsmce2^{Gt(AA0032)Wtsi} involves: 129P2/OlaHsd * C57BL/6	abnormal cell mass	J:227197
	abnormal cell nucleus morphology	J:227197
	abnormal chromosome morphology	J:227197
	embryonic lethality before implantation	J:227197
Nsmce2^tm1.1Ofc/Nsmce2^tm1.1Ofc involves: 129 * C57BL/6 * SJL	no abnormal phenotype detected	J:227197
Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal cell nucleus morphology	J:227197
	abnormal coat/hair pigmentation	J:227197
	abnormal intestinal epithelium morphology	J:227197
	abnormal mitosis	J:227197
	abnormal skin pigmentation	J:227197
	abnormal thymus physiology	J:227197
	anemia	J:227197
	decreased embryo size	J:227197
	decreased total body fat amount	J:227197
	elevated level of mitotic sister chromatid exchange	J:227197
	mitotic nondisjunction	J:227197
	premature aging	J:227197
	premature death	J:227197

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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