Rnf146 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rnf146
ring finger protein 146
MGI:1915281

38 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal compact bone morphology	J:243612
	abnormal osteoclast differentiation	J:243612
	decreased bone mineral density	J:243612
	decreased bone trabecula number	J:243612
	decreased compact bone thickness	J:243612
	decreased trabecular bone mass	J:243612
	decreased trabecular bone volume	J:243612
	increased bone trabecular spacing	J:243612
	increased circulating tumor necrosis factor level	J:243612
	increased osteoclast cell number	J:243612
	normal skeleton phenotype	J:243612
Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: C57BL/6J * CD-1	abnormal alveolar process morphology	J:244583
	abnormal ameloblast differentiation	J:244583
	abnormal endochondral bone ossification	J:244583
	abnormal intramembranous bone ossification	J:244583
	abnormal limb long bone morphology	J:244583
	abnormal rib morphology	J:244583
	clavicle hypoplasia	J:244583
	decreased bone mineral density	J:244583
	decreased bone mineralization	J:244583
	decreased bone ossification	J:244583
	decreased bone trabecula number	J:244583
	decreased circulating insulin level	J:244583
	decreased circulating osteocalcin level	J:244583
	decreased compact bone thickness	J:244583
	decreased compact bone volume	J:244583
	decreased insulin secretion	J:244583
	decreased osteoblast cell number	J:244583
	decreased osteoblast proliferation	J:244583
	decreased pancreatic islet number	J:244583
	decreased trabecular bone volume	J:244583
	impaired glucose tolerance	J:244583
	impaired osteoblast differentiation	J:244583
	increased bone marrow adipose tissue amount	J:244583
	increased bone trabecular spacing	J:244583
	increased circulating glucose level	J:244583
	increased circulating triglyceride level	J:244583
	increased total body fat amount	J:244583
	large anterior fontanelle	J:244583
	large posterior fontanelle	J:244583
	neonatal lethality, complete penetrance	J:244583
	respiratory distress	J:244583
	normal skeleton phenotype	J:244583
	small pancreatic islets	J:244583

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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