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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Chd8
chromodomain helicase DNA binding protein 8
MGI:1915022
33 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Chd8em1(IMPC)Mbp/Chd8+
C57BL/6N-Chd8em1(IMPC)Mbp/MbpMmucd
decreased circulating cholesterol level J:211773
decreased monocyte cell number J:211773
decreased startle reflex J:211773
decreased vertical activity J:211773
impaired glucose tolerance J:211773
increased lymphocyte cell number J:211773
Chd8em1(IMPC)Mbp/Chd8em1(IMPC)Mbp
C57BL/6N-Chd8em1(IMPC)Mbp/MbpMmucd
preweaning lethality, complete penetrance J:211773
Chd8tm1.1Csbd/Chd8+
involves: C57BL/6J
abnormal brain morphology J:267025
abnormal miniature inhibitory postsynaptic currents J:267025
abnormal nervous system electrophysiology J:267025
abnormal neuron physiology J:267025
abnormal social/conspecific interaction J:267025
excessive vocalization J:267025
hypoactivity J:267025
increased grooming behavior J:267025
increased thigmotaxis J:267025
Chd8tm1Kei/Chd8+
Not Specified
abnormal intestinal transit time J:235128
abnormal social investigation J:235128
decreased intestine length J:235128
decreased startle reflex J:235128
increased anxiety-related response J:235128
increased brain weight J:235128
increased prepulse inhibition J:235128
megacephaly J:235128
Chd8tm1Kei/Chd8tm1Kei
involves: C57BL/6
abnormal inner cell mass morphology J:92968
absent mesoderm J:92968
embryonic growth arrest J:92968
embryonic lethality, complete penetrance J:92968
failure of primitive streak formation J:92968
increased ectoderm apoptosis J:92968
inner cell mass degeneration J:92968
Chd8tm2.1Kei/Chd8+
B6J.129P2-Chd8tm2.1Kei
abnormal intestinal transit time J:235128
abnormal nervous system development J:235128
abnormal social investigation J:235128
decreased intestine length J:235128
decreased startle reflex J:235128
impaired learning J:235128
increased anxiety-related response J:235128
increased brain weight J:235128
increased prepulse inhibition J:235128
megacephaly J:235128
Chd8tm2.1Kei/Chd8tm2.1Kei
involves: 129P2/OlaHsd * C57BL/6J
embryonic lethality during organogenesis, complete penetrance J:235128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory