Rnaseh2b Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rnaseh2b
ribonuclease H2, subunit B
MGI:1914403

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ifnar1^tm1Agt/Ifnar1^tm1Agt Rnaseh2b^{tm1a(EUCOMM)Wtsi}/Rnaseh2b^{tm1a(EUCOMM)Wtsi} involves: 129S2/SvPas * C57BL/6N	decreased fetal size	J:186986
	perinatal lethality, complete penetrance	J:186986
Rnaseh2b^em1Anu/Rnaseh2b⁺ Tlr7^em2Anu/Tlr7⁺ C57BL/6NCrl-Rnaseh2b^em1Anu Tlr7^em2Anu	abnormal immune system morphology	J:324448
	abnormal mature B cell morphology	J:324448
	increased autoantibody level	J:324448
	increased CD4-positive, alpha-beta T cell number	J:324448
	increased germinal center B cell number	J:324448
	increased plasma cell number	J:324448
	increased T follicular helper cell number	J:324448
Rnaseh2b^{tm1a(EUCOMM)Wtsi}/Rnaseh2b^{tm1a(EUCOMM)Wtsi} Trp53^tm1Mlh/Trp53^tm1Mlh involves: 129P2/OlaHsd * C57BL/6N	abnormal cell nucleus morphology	J:186180
	abnormal neural tube closure	J:186180
	normal cellular phenotype	J:186180
	chromosomal instability	J:186180
	decreased embryo size	J:186180
	normal embryo phenotype	J:186180
	embryonic growth retardation	J:186180
	increased cellular sensitivity to alkylating agents	J:186180

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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