Mcm8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mcm8
minichromosome maintenance 8 homologous recombination repair factor
MGI:1913884

26 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Mcm8^tm1.1Geno/Mcm8^tm1.1Geno involves: 129S2/SvPas * C57BL/6J	abnormal cell nucleus morphology	J:187623
	abnormal DNA replication	J:187623
	abnormal double-strand DNA break repair	J:187623
	abnormal male germ cell apoptosis	J:187623
	abnormal oocyte morphology	J:187623
	abnormal ovary morphology	J:187623
	abnormal primary ovarian follicle morphology	J:187623
	absent mature ovarian follicles	J:187623
	arrest of male meiosis	J:187623
	azoospermia	J:187623
	decreased fibroblast proliferation	J:187623
	decreased oocyte number	J:187623
	decreased testis weight	J:187623
	endometrium hyperplasia	J:187623
	female infertility	J:187623
	impaired ovarian folliculogenesis	J:187623
	increased cellular sensitivity to gamma-irradiation	J:187623
	increased ovary adenoma incidence	J:187623
	increased ovary tumor incidence	J:187623
	male infertility	J:187623
	polyploidy	J:187623
	small ovary	J:187623
	small seminiferous tubules	J:187623
	small testis	J:187623
	spontaneous chromosome breakage	J:187623
	testicular atrophy	J:187623

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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