Rad18 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rad18
RAD18 E3 ubiquitin protein ligase
MGI:1890476

28 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rad18^{tm1a(EUCOMM)Wtsi}/Rad18^{tm1a(EUCOMM)Wtsi} B6Brd;B6Dnk;B6N-Tyr^c-Brd Rad18^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal arrector pilli muscle morphology	J:232539
Rad18^{tm1a(EUCOMM)Wtsi}/Rad18^{tm1a(EUCOMM)Wtsi} B6JTyr;B6N-Rad18^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal coat/ hair morphology	J:175295
	abnormal hair texture	J:175295
	decreased body weight	J:165965, J:175295
	decreased locomotor activity	J:175295
	decreased total body fat amount	J:165965
	increased hematocrit	J:165965
	increased mean corpuscular hemoglobin concentration	J:175295
	increased mean corpuscular volume	J:165965
Rad18^{tm1a(EUCOMM)Wtsi}/Rad18^{tm1a(EUCOMM)Wtsi} involves: C57BL/6 * C57BL/6N	abnormal liver physiology	J:213427
	chromosomal instability	J:213427
	decreased body weight	J:213427
	hyperactivity	J:213427
	increased carbon dioxide production	J:213427
	increased energy expenditure	J:213427
	increased oxygen consumption	J:213427
Rad18^tm1Stat/Rad18^tm1Stat B6.Cg-Rad18^tm1Stat	abnormal spermatogonia morphology	J:145534
	decreased male germ cell number	J:145534
	decreased testis weight	J:145534
	normal homeostasis/metabolism phenotype	J:145534
	reduced male fertility	J:145534
	seminiferous tubule degeneration	J:145534
Gt(ROSA)26Sor/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal double-strand DNA break repair	J:177475
	abnormal spermatid morphology	J:177475
	abnormal synaptonemal complex	J:177475
	decreased body weight	J:177475
	decreased epididymis weight	J:177475
	decreased litter size	J:177475
	decreased testis weight	J:177475
	oligozoospermia	J:177475
Gt(ROSA)26Sor/Gt(ROSA)26Sor involves: 129S6/SvEvTac * C57BL/6	preweaning lethality, complete penetrance	J:177475

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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