Fntb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fntb
farnesyltransferase, CAAX box, beta
MGI:1861305

22 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fntb^tm1.1Bbd/Fntb^tm1.1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal ectoderm development	J:98944
	decreased inner cell mass proliferation	J:98944
	embryonic lethality during organogenesis, complete penetrance	J:98944
Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg involves: 129P2/OlaHsd * C57BL/6	abnormal cell cycle	J:158937
	abnormal cell morphology	J:158937
	decreased fibroblast proliferation	J:158937
Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Tg(KRT14-cre)1Amc/? involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal hair follicle orientation	J:158528
	abnormal hair shaft morphology	J:158528
	abnormal keratinocyte morphology	J:158528
	alopecia	J:158528
	decreased body size	J:158528
	decreased hair follicle number	J:158528
	decreased keratinocyte proliferation	J:158528
	increased hair follicle apoptosis	J:158528
	underdeveloped hair follicles	J:158528
Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * FVB/N	abnormal cell cycle	J:158937
	abnormal cell morphology	J:158937
	decreased fibroblast proliferation	J:158937
Fntb^{tm1b(EUCOMM)Hmgu}/Fntb⁺ C57BL/6N-Fntb^{tm1b(EUCOMM)Hmgu}/Nju	thrombocytopenia	J:211773
Fntb^{tm1b(EUCOMM)Hmgu}/Fntb^{tm1b(EUCOMM)Hmgu} C57BL/6N-Fntb^{tm1b(EUCOMM)Hmgu}/Nju	preweaning lethality, complete penetrance	J:211773
Fntb^tm1Bbd/Fntb^tm1.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	abnormal hematopoietic system physiology	J:98944
	decreased cell proliferation	J:98944
	decreased incidence of tumors by chemical induction	J:98944
	delayed wound healing	J:98944
	small spleen	J:98944
Fntb^tm1Bbd/Fntb^tm1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	abnormal hematopoietic system physiology	J:98944
	decreased cell proliferation	J:98944
	decreased incidence of tumors by chemical induction	J:98944
	delayed wound healing	J:98944
	small spleen	J:98944

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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