Arhgef7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arhgef7
Rho guanine nucleotide exchange factor
MGI:1860493

17 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arhgef7^{tm1a(EUCOMM)Wtsi}/Arhgef7^{tm1a(EUCOMM)Wtsi} C57BL/6N-Arhgef7^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal placenta morphology	J:261316
	lethality throughout fetal growth and development, complete penetrance	J:261316
	preweaning lethality, complete penetrance	J:211773
Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: C57BL/6N * CBA	normal embryo phenotype	J:217373
Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi} Tg(Ttr-cre)1Hadj/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal anterior visceral endoderm cell migration	J:217373
	abnormal primitive streak morphology	J:217373
Arhgef7^{tm1d(EUCOMM)Wtsi}/Arhgef7^{tm1d(EUCOMM)Wtsi} involves: C57BL/6N * CBA	abnormal anterior visceral endoderm cell migration	J:217373
	abnormal embryo development	J:217373
	abnormal primitive streak morphology	J:217373
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:217373
Arhgef7^tm1Dprk/Arhgef7^tm1Dprk involves: 129S4/SvJae * C57BL/6J	abnormal allantois morphology	J:284300
	abnormal chorion morphology	J:284300
	abnormal embryo turning	J:284300
	decreased embryo size	J:284300
	decreased fibroblast chemotaxis	J:284300
	embryonic growth retardation	J:284300
	embryonic lethality during organogenesis, complete penetrance	J:284300
	incomplete rostral neuropore closure	J:284300
	increased fibroblast cell migration	J:284300

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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