Insm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Insm1
insulinoma-associated 1
MGI:1859980

36 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Insm1^tm1.1Jga/Insm1^tm1.1Jga either: B6.129P2-Insm1^tm1.1Jga or (involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N)	abnormal neuron differentiation	J:168833
	abnormal olfactory epithelium morphology	J:168833
	decreased neuron number	J:168833
	embryonic lethality during organogenesis, incomplete penetrance	J:168833
	increased neuron apoptosis	J:168833
	lethality throughout fetal growth and development, complete penetrance	J:168833
Insm1^tm1.1Mgn/Insm1^tm1.1Mgn involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL	lethality, complete penetrance	J:94077
Insm1^tm1.1Mgn/Insm1^tm1.1Mgn involves: 129S6/SvEvTac * CD-1 * SJL	abnormal endocrine pancreas development	J:214095
	abnormal endocrine pancreas morphology	J:214095
	abnormal pancreatic endocrine progenitor cell physiology	J:214095
	decreased pancreatic endocrine progenitor cell proliferation	J:214095
	lethality throughout fetal growth and development	J:214095
Insm1^tm1Cbm/Insm1^tm1Cbm involves: 129P2/OlaHsd	abnormal pituitary gland development	J:206319
	absent somatotrophs	J:206319
	absent thyrotrophs	J:206319
	decreased adrenocorticotropin level	J:206319
	decreased follicle stimulating hormone level	J:206319
	decreased growth hormone level	J:206319
	decreased luteinizing hormone level	J:206319
	decreased pituitary hormone level	J:206319
	decreased prolactin level	J:206319
	decreased thyroid-stimulating hormone level	J:206319
	small pituitary gland	J:206319
Insm1^tm1Cbm/Insm1^tm1Cbm involves: 129P2/OlaHsd * C57BL/6	cyanosis	J:112173
	decreased pancreatic beta cell number	J:112173
	neonatal lethality, complete penetrance	J:112173
	perinatal lethality, incomplete penetrance	J:112173
	respiratory failure	J:112173
Insm1^tm1Cbm/Insm1^tm1Cbm involves: 129P2/OlaHsd * C57BL/6 * CD-1	abnormal endocrine pancreas development	J:112173
	abnormal enteroendocrine cell morphology	J:112173
	absent PP cells	J:112173
	cyanosis	J:112173
	decreased pancreatic alpha cell number	J:112173
	decreased pancreatic beta cell number	J:112173
	decreased pancreatic delta cell number	J:112173
	decreased pancreatic epsilon cell number	J:112173
	increased pancreas apoptosis	J:112173
	increased PP cell number	J:112173
	neonatal lethality, complete penetrance	J:112173
	pancreatic islet hypoplasia	J:112173
	perinatal lethality, incomplete penetrance	J:112173
	respiratory failure	J:112173
Insm1^tm1Cbm/Insm1^tm2.1Cbm involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	decreased adrenocorticotropin level	J:206319
	decreased follicle stimulating hormone level	J:206319
	decreased growth hormone level	J:206319
	decreased luteinizing hormone level	J:206319
	decreased pituitary hormone level	J:206319
	decreased prolactin level	J:206319
	decreased thyroid-stimulating hormone level	J:206319

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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