Icos Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Icos
inducible T cell co-stimulator
MGI:1858745

55 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Icos^tm1.1Wks/Icos^tm1.1Wks involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal B cell number	J:155586
	abnormal B cell physiology	J:155586
	abnormal B cell selection	J:155586
	abnormal class switch recombination	J:155586
	abnormal immune system physiology	J:155586
	abnormal Peyer's patch germinal center morphology	J:155586
	abnormal spleen morphology	J:155586
	decreased CD4-positive, alpha-beta T cell number	J:155586
	decreased IgA level	J:155586
	decreased IgG1 level	J:155586
	decreased IgG2b level	J:155586
	decreased IgG2c level	J:155586
	decreased interleukin-4 secretion	J:155586
	decreased interleukin-21 secretion	J:155586
	decreased spleen germinal center number	J:155586
	small Peyer's patches	J:155586
Icos^tm1Dgry/Icos^tm1Dgry B6.129P2-Icos^tm1Dgry	abnormal CD4-positive, alpha-beta T cell physiology	J:123477
	abnormal immune system physiology	J:123477
	abnormal interleukin secretion	J:123477
	abnormal leukocyte cell number	J:123477
	abnormal memory B cell number	J:123477
	abnormal response to infection	J:123477
	abnormal T cell physiology	J:123477
	decreased germinal center B cell number	J:123477
	decreased IgG level	J:123477
	decreased interleukin-4 secretion	J:123477
	decreased interleukin-5 secretion	J:123477
	decreased plasma cell number	J:123477
	increased plasma cell number	J:123477
Icos^tm1Flv/Icos⁺ NOD.129S1-Icos^tm1Flv	decreased pancreatic islet number	J:131529
Icos^tm1Flv/Icos⁺ NOD.129S1-Icos^tm1Flv	insulitis	J:131529
Icos^tm1Flv/Icos^tm1Flv involves: 129/Sv * C57BL/6	abnormal immunoglobulin level	J:87123
	abnormal interferon level	J:87123
	abnormal interleukin level	J:87123
	abnormal T-helper 2 physiology	J:87123
	decreased IgE level	J:87123
	decreased IgG1 level	J:87123
	normal immune system phenotype	J:87123
	increased susceptibility to experimental autoimmune encephalomyelitis	J:87123
	small lymph nodes	J:87123
Icos^tm1Flv/Icos^tm1Flv involves: 129S1/Sv	abnormal cytokine secretion	J:112600
Icos^tm1Flv/Icos^tm1Flv NOD.129S1-Icos^tm1Flv	decreased anti-insulin autoantibody level	J:131529
	decreased autoantibody level	J:131529
	decreased IgG level	J:131529
	decreased interferon-gamma secretion	J:131529
	decreased susceptibility to autoimmune diabetes	J:131529
	decreased T cell number	J:131529
	normal endocrine/exocrine gland phenotype	J:131529
	normal immune system phenotype	J:131529
	insulitis	J:131529
Icos^tm1Mak/Icos^tm1Mak involves: 129P2/OlaHsd * C57BL/6	abnormal B cell number	J:155586
	abnormal B cell physiology	J:66702
	abnormal class switch recombination	J:66702
	abnormal immune system physiology	J:66702
	abnormal Peyer's patch germinal center morphology	J:155586
	abnormal spleen morphology	J:66702
	abnormal T cell physiology	J:66702
	decreased CD4-positive, alpha-beta T cell number	J:155586
	decreased IgA level	J:155586
	decreased IgE level	J:66702
	decreased IgG1 level	J:66702, J:155586
	decreased IgG2b level	J:155586
	decreased IgG2c level	J:155586
	decreased interleukin-21 secretion	J:155586
	decreased spleen germinal center number	J:66702, J:155586
	decreased spleen germinal center size	J:66702
	decreased T cell proliferation	J:66702
	small Peyer's patches	J:155586
Icos^tm1Shr/Icos^tm1Shr Not Specified	abnormal CD4-positive, alpha-beta T cell physiology	J:87124
	abnormal immunoglobulin level	J:87124
	abnormal interleukin level	J:87124
	abnormal spleen germinal center morphology	J:87124
	abnormal T cell differentiation	J:87124
	decreased IgE level	J:87124
	decreased IgG1 level	J:87124
	decreased IgG2a level	J:87124
	decreased IgG level	J:87124
	increased IgG3 level	J:87124
Icos^tm1Tkan/Icos^tm1Tkan involves: 129S7/SvEvBrd * C57BL/6	abnormal NK cell physiology	J:95353
	abnormal Peyer's patch germinal center morphology	J:95728
	abnormal small intestine morphology	J:95728
	decreased circulating interferon-gamma level	J:95353
	decreased circulating interleukin-4 level	J:95353
	small Peyer's patches	J:95728
Icos^{tm2b(EUCOMM)Wtsi}/Icos^{tm2b(EUCOMM)Wtsi} C57BL/6N-Icos^{tm2b(EUCOMM)Wtsi}/Orl	short tibia	J:211773

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