Phgdh Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Phgdh
3-phosphoglycerate dehydrogenase
MGI:1355330

48 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Phgdh^tm1.1Shfu/Phgdh^tm1.1Shfu involves: 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal brain development	J:128777
	abnormal embryonic neuroepithelial layer differentiation	J:128777
	abnormal embryonic/fetal subventricular zone morphology	J:128777
	abnormal nervous system development	J:128777
	abnormal neuron differentiation	J:128777
	absent cerebellum	J:128777
	absent olfactory bulb	J:128777
	decreased brain size	J:128777
	decreased embryo size	J:128777
	embryonic lethality during organogenesis, complete penetrance	J:128777
	enlarged lateral ventricles	J:128777
	exencephaly	J:128777
	forebrain hypoplasia	J:128777
	interdigital webbing	J:128777
Phgdh^tm1.2Shfu/Phgdh^tm1.2Shfu Tg(GFAP-cre)25Mes/0 involves: 129P2/OlaHsd * FVB/N	decreased arginine level	J:167572
	decreased brain weight	J:167572
	decreased cystathionine level	J:167572
	decreased glutamic acid level	J:167572
	decreased glycine level	J:167572
	decreased phenylalanine level	J:167572
	decreased serine level	J:167572
	decreased threonine level	J:167572
	forebrain hypoplasia	J:167572
	increased arginine level	J:167572
	increased circulating glycine level	J:167572
	increased glutamine level	J:167572
	increased phenylalanine level	J:167572
	microcephaly	J:167572
Phgdh^{tm1b(KOMP)Wtsi}/Phgdh⁺ C57BL/6N-Phgdh^{tm1b(KOMP)Wtsi}/Kmpc	decreased fluid intake	J:211773
	decreased food intake	J:211773
	decreased respiratory quotient	J:211773
	no spontaneous movement	J:211773
	unresponsive to tactile stimuli	J:211773
Phgdh^{tm1b(KOMP)Wtsi}/Phgdh^{tm1b(KOMP)Wtsi} C57BL/6N-Phgdh^{tm1b(KOMP)Wtsi}/Kmpc	abnormal blood vessel morphology	J:211773
	abnormal embryo development	J:211773
	abnormal embryo size	J:211773
	abnormal embryo turning	J:211773
	abnormal eye morphology	J:211773
	abnormal head shape	J:211773
	abnormal head size	J:211773
	abnormal hindbrain morphology	J:211773
	abnormal visceral yolk sac morphology	J:211773
	abnormal vitelline vasculature morphology	J:211773
	edema	J:211773
	embryonic growth retardation	J:211773
	hemorrhage	J:211773
	microphthalmia	J:211773
	prenatal lethality	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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