Il22 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il22
interleukin 22
MGI:1355307

35 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il22^tm1.1Lex/Il22^tm1.1Lex involves: 129S5/SvEvBrd	abnormal circulating cytokine level	J:179011
	abnormal colon morphology	J:161073
	abnormal large intestine crypts of Lieberkuhn morphology	J:161073
	colitis	J:161073
	decreased body weight	J:161073
	decreased circulating interleukin-1 alpha level	J:179011
	decreased circulating interleukin-12 level	J:179011
	decreased circulating interleukin-12b level	J:179011
	decreased circulating tumor necrosis factor level	J:179011
	increased circulating interleukin-17 level	J:179011
	increased susceptibility to bacterial infection induced morbidity/mortality	J:161073
	increased susceptibility to fungal infection	J:179011
	lung inflammation	J:179011
	multifocal hepatic necrosis	J:161073
Il22^tm1.1Lex/Il22^tm1.1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal cytokine secretion	J:118261
	acanthosis	J:118261
	ear inflammation	J:118261
	mixed cellular infiltration to dermis	J:118261
	thick dermal layer	J:118261
Il22^tm1Flv/Il22⁺ B6.Cg-Il22^tm1Flv	increased physiological sensitivity to xenobiotic	J:126103
Il22^tm1Flv/Il22⁺ B6.Cg-Il22^tm1Flv	increased susceptibility to endotoxin shock	J:126103
Il22^tm1Flv/Il22^tm1Flv B6.Cg-Il22^tm1Flv	increased circulating alanine transaminase level	J:126103
	increased circulating aspartate transaminase level	J:126103
	increased physiological sensitivity to xenobiotic	J:126103
	increased susceptibility to endotoxin shock	J:126103
	liver inflammation	J:126103
Il22^tm1Flv/Il22^tm1Flv involves: 129/Sv * C57BL/6	increased incidence of tumors by chemical induction	J:189217
Il22^tm1Flv/Il22^tm1Flv involves: 129/Sv * C57BL/6	increased susceptibility to induced colitis	J:189217
Il22^tm1Jcrd/Il22^tm1Jcrd B6.Cg-Il22^tm1Jcrd	normal immune system phenotype	J:155038
Il22^tm1Jcrd/Il22^tm1Jcrd Not Specified	decreased neutrophil cell number	J:193548
	decreased physiological sensitivity to xenobiotic	J:193548
	increased interleukin-17 secretion	J:193548
Il22^tm1Vlcg/Il22^tm1Vlcg Not Specified	abnormal skin morphology	J:197959
	abnormal wound healing	J:197959
	delayed wound healing	J:197959
Tg(Fabp4-Il22)#Ychn/0 involves: ICR	normal homeostasis/metabolism phenotype	J:176141
Tg(Fabp4-Il22)#Ychn/0 involves: ICR	increased liposarcoma incidence	J:176141

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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