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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
MGI:1353510
40 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
C57BL/6-Arhgef1tm1.1Rmt
abnormal marginal zone B cell physiology J:113295
decreased B cell number J:113295
decreased B-1 B cell number J:113295
decreased follicular B cell number J:113295
decreased IgM level J:113295
decreased marginal zone B cell number J:113295
Arhgef1tm1a(EUCOMM)Wtsi/Arhgef1tm1a(EUCOMM)Wtsi
C57BL/6N-Arhgef1tm1a(EUCOMM)Wtsi/Wtsi
decreased CD8-positive, alpha-beta T cell number J:211773
decreased dendritic cell number J:211773
decreased immature NK cell number J:211773
decreased Ly6C-positive immature NK cell number J:211773
decreased marginal zone B cell number J:211773
decreased memory-marker CD4-positive NK T cell number J:211773
decreased memory-marker gamma-delta T cell number J:211773
increased CD4-positive, alpha beta T cell number J:211773
increased effector memory CD4-positive, alpha-beta T cell number J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased gamma-delta T cell number J:211773
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased KLRG1-positive NK cell number J:211773
increased Ly6C low monocyte number J:211773
increased Ly6C-positive NK T cell number J:211773
increased mature NK cell number J:211773
increased monocyte cell number J:211773
increased plasmacytoid dendritic cell number J:211773
preweaning lethality, incomplete penetrance J:211773
Arhgef1tm1Djle/Arhgef1tm1Djle
involves: 129S4/SvJae
increased germinal center B cell number J:174313
Arhgef1tm1Djle/Arhgef1tm1Djle
involves: 129S4/SvJae * C57BL/6
abnormal neutrophil physiology J:129331
enlarged spleen J:129331
extramedullary hematopoiesis J:129331
increased leukocyte cell number J:129331
Arhgef1tm1Kdf/Arhgef1tm1Kdf
involves: 129S1/Sv * 129X1/SvJ
abnormal humoral immune response J:99463
abnormal lymphocyte cell number J:99463
abnormal lymphocyte physiology J:99463
decreased B cell number J:99463
decreased B cell proliferation J:99463
decreased IgG level J:99463
decreased IgM level J:99463
decreased marginal zone B cell number J:99463
increased T cell proliferation J:99463
Arhgef1tm1Rmt/Arhgef1tm1Rmt
X/Tg(Myh11-cre/ERT2)1Soff
involves: C57BL/6 * FVB/N
abnormal aorta wall morphology J:157074
abnormal systemic arterial blood pressure J:157074
cardiac hypertrophy J:157074
decreased physiological sensitivity to xenobiotic J:157074
decreased vasoconstriction J:157074

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory