About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Arhgef1
Rho guanine nucleotide exchange factor 1
MGI:1353510
44 phenotypes from 5 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
C57BL/6-Arhgef1tm1.1Rmt 		abnormal marginal zone B cell physiology J:113295
decreased B cell number J:113295
decreased B-1 B cell number J:113295
decreased follicular B cell number J:113295
decreased IgM level J:113295
decreased marginal zone B cell number J:113295
Arhgef1tm1a(EUCOMM)Wtsi/Arhgef1tm1a(EUCOMM)Wtsi
C57BL/6N-Arhgef1tm1a(EUCOMM)Wtsi/Wtsi 		decreased CD8-positive, alpha-beta T cell number J:211773
decreased dendritic cell number J:211773
decreased immature NK cell number J:211773
decreased Ly6C-positive immature NK cell number J:211773
decreased marginal zone B cell number J:211773
decreased memory-marker CD4-positive NK T cell number J:211773
decreased memory-marker gamma-delta T cell number J:211773
increased CD4-positive, alpha-beta memory T cell number J:211773
increased CD4-positive, alpha-beta T cell number J:211773
increased CD8-positive, alpha-beta memory T cell number J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased erythrocyte cell number J:211773
increased gamma-delta T cell number J:211773
increased hematocrit J:211773
increased hemoglobin content J:211773
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased KLRG1-positive NK cell number J:211773
increased Ly6C low monocyte number J:211773
increased Ly6C-positive NK T cell number J:211773
increased mature NK cell number J:211773
increased monocyte cell number J:211773
increased plasmacytoid dendritic cell number J:211773
preweaning lethality, incomplete penetrance J:211773
Arhgef1tm1Djle/Arhgef1tm1Djle
involves: 129S4/SvJae 		increased germinal center B cell number J:174313
Arhgef1tm1Djle/Arhgef1tm1Djle
involves: 129S4/SvJae * C57BL/6 		abnormal neutrophil physiology J:129331
enlarged spleen J:129331
extramedullary hematopoiesis J:129331
increased leukocyte cell number J:129331
Arhgef1tm1Kdf/Arhgef1tm1Kdf
involves: 129S1/Sv * 129X1/SvJ 		abnormal humoral immune response J:99463
abnormal lymphocyte cell number J:99463
abnormal lymphocyte physiology J:99463
decreased B cell number J:99463
decreased B cell proliferation J:99463
decreased IgG level J:99463
decreased IgM level J:99463
decreased marginal zone B cell number J:99463
increased T cell proliferation J:99463
Arhgef1tm1Rmt/Arhgef1tm1Rmt
X/Tg(Myh11-icre/ERT2)1Soff
involves: C57BL/6 * FVB/N 		abnormal aorta wall morphology J:157074
abnormal systemic arterial blood pressure J:157074
cardiac hypertrophy J:157074
decreased physiological sensitivity to xenobiotic J:157074
decreased vasoconstriction J:157074
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory