Abcb11 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abcb11
ATP-binding cassette, sub-family B member 11
MGI:1351619

26 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abcb11^{tm1a(EUCOMM)Hmgu}/Abcb11^{tm1a(EUCOMM)Hmgu} C57BL/6N-Abcb11^{tm1a(EUCOMM)Hmgu}/Ieg	abnormal retina morphology	J:165965
	increased circulating alanine transaminase level	J:165965
	increased circulating alkaline phosphatase level	J:165965
	increased circulating aspartate transaminase level	J:165965
	increased circulating potassium level	J:165965
	increased lean body mass	J:165965
Abcb11^{tm1b(EUCOMM)Hmgu}/Abcb11⁺ C57BL/6N-Abcb11^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lung morphology	J:211773
	decreased circulating triglyceride level	J:211773
	decreased locomotor activity	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating amylase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating fructosamine level	J:211773
	increased circulating unsaturated transferrin level	J:211773
Abcb11^{tm1b(EUCOMM)Hmgu}/Abcb11^{tm1b(EUCOMM)Hmgu} C57BL/6N-Abcb11^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, incomplete penetrance	J:211773
Abcb11^tm1Wng/Abcb11^tm1Wng involves: 129S6/SvEvTac * C57BL/6J	abnormal bile canaliculus morphology	J:67548
	abnormal bile salt level	J:67548
	abnormal bile secretion	J:67548
	abnormal hepatocyte morphology	J:67548
	abnormal phospholipid level	J:67548
	decreased body weight	J:67548
	decreased liver glycogen level	J:67548
	enlarged liver	J:67548
	increased bile salt level	J:67548
	increased cholesterol level	J:67548
	intrahepatic cholestasis	J:67548
	postnatal growth retardation	J:67548

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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