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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
MGI:1349419
83 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aifm1Hq/Y
B6CBACa Aw-J/A-Aifm1Hq/J 		abnormal cardiovascular system morphology J:110278
abnormal cardiovascular system physiology J:110278
abnormal cell cycle J:78983
abnormal cerebellar cortex morphology J:78983
abnormal cerebellar granule cell morphology J:78983
abnormal cerebellar granule layer morphology J:78983, J:79052
abnormal eye electrophysiology J:78983
abnormal gait J:79052
abnormal motor capabilities/coordination/movement J:79052
abnormal myocardial fiber physiology J:110278
abnormal respiratory electron transport chain J:144096
abnormal response to cardiac infarction J:110278
abnormal seizure response to pharmacological agent J:98103
absent optic nerve J:144096
alopecia J:144096
amacrine cell degeneration J:78983
ataxia J:79052, J:144096
cardiac hypertrophy J:110278
decreased birth weight J:144096
decreased body size J:144096
decreased body weight J:144096
decreased cardiac muscle contractility J:110278
decreased susceptibility to neuronal excitotoxicity J:98103
dilated heart left ventricle J:110278
impaired coordination J:144096
increased cardiomyocyte apoptosis J:110278
increased catalase activity J:78983, J:144096
increased cellular sensitivity to hydrogen peroxide J:78983
increased myocardial infarct size J:110278
increased superoxide dismutase level J:144096
increased susceptibility to age-related retinal degeneration J:78983
increased susceptibility to induced morbidity/mortality J:110278
oxidative stress J:78983, J:110278
postnatal growth retardation J:144096
premature death J:144096
Purkinje cell degeneration J:78983, J:79052
retina ganglion cell degeneration J:78983
small cerebellum J:78983
sparse hair J:79052
thin retina inner plexiform layer J:78983
thin retina outer plexiform layer J:78983
tremors J:79052
Aifm1Hq/Aifm1+
B6CBACa Aw-J/A-Aifm1Hq/J 		normal behavior/neurological phenotype J:79052
normal nervous system phenotype J:79052
sparse hair J:79052
Aifm1Hq/Y
involves: CF-1 		decreased body weight J:15073
focal hair loss J:15073
Aifm1Hq/Aifm1Hq
B6CBACa Aw-J/A-Aifm1Hq/J 		abnormal cardiovascular system morphology J:110278
abnormal cardiovascular system physiology J:110278
abnormal cell cycle J:78983
abnormal cerebellar cortex morphology J:78983
abnormal cerebellar granule cell morphology J:78983
abnormal cerebellar granule layer morphology J:78983, J:79052
abnormal eye electrophysiology J:78983
abnormal gait J:79052
abnormal motor capabilities/coordination/movement J:79052
abnormal myocardial fiber physiology J:110278
abnormal respiratory electron transport chain J:144096
abnormal response to cardiac infarction J:110278
abnormal seizure response to pharmacological agent J:98103
absent optic nerve J:144096
alopecia J:144096
amacrine cell degeneration J:78983
ataxia J:79052, J:144096
cardiac hypertrophy J:110278
decreased birth weight J:144096
decreased body size J:144096
decreased body weight J:144096
decreased cardiac muscle contractility J:110278
decreased susceptibility to neuronal excitotoxicity J:98103
dilated heart left ventricle J:110278
impaired coordination J:144096
increased cardiomyocyte apoptosis J:110278
increased catalase activity J:78983, J:144096
increased cellular sensitivity to hydrogen peroxide J:78983
increased myocardial infarct size J:110278
increased superoxide dismutase level J:144096
increased susceptibility to age-related retinal degeneration J:78983
increased susceptibility to induced morbidity/mortality J:110278
oxidative stress J:78983, J:110278
premature death J:144096
Purkinje cell degeneration J:78983, J:79052
retina ganglion cell degeneration J:78983
small cerebellum J:78983
sparse hair J:79052
thin retina inner plexiform layer J:78983
thin retina outer plexiform layer J:78983
tremors J:79052
Aifm1Hq/Aifm1Hq
involves: CF-1 		decreased body weight J:15073
focal hair loss J:15073
Aifm1tm1Pngr/Y
129P2/OlaHsd-Aifm1tm1Pngr 		abnormal cell physiology J:68434
Aifm1tm2.1Pngr/Aifm1+
involves: 129P2/OlaHsd * FVB/N 		embryonic lethality, incomplete penetrance J:111066
Aifm1tm2.1Pngr/Y
involves: 129P2/OlaHsd * FVB/N 		abnormal respiratory electron transport chain J:111066
decreased brain size J:111066
decreased embryo size J:111066
decreased somite size J:111066
embryonic lethality during organogenesis, complete penetrance J:111066
increased embryonic tissue cell apoptosis J:111066
Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
involves: 129P2/OlaHsd * FVB/N 		abnormal respiratory electron transport chain J:111066
decreased brain size J:111066
decreased embryo size J:111066
decreased somite size J:111066
embryonic lethality during organogenesis, complete penetrance J:111066
increased embryonic tissue cell apoptosis J:111066
Aifm1tm2Pngr/Aifm1+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB/N 		decreased body size J:113016
prenatal lethality, incomplete penetrance J:113016
Aifm1tm2Pngr/Y
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd 		abnormal enzyme/coenzyme level J:112874
abnormal mitochondrial morphology J:112874
abnormal mitochondrial physiology J:112874
decreased mitochondrial fission J:112874
decreased neuron apoptosis J:112874
increased neuron apoptosis J:112874
lethality throughout fetal growth and development, incomplete penetrance J:112874
thin cerebral cortex J:112874
Aifm1tm2Pngr/Y
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * FVB 		abnormal aerobic respiration J:113016
abnormal glucose homeostasis J:113016
abnormal heart ventricle pressure J:113016
abnormal hormone level J:113016
abnormal mitochondrial ATP synthesis coupled electron transport J:113016
abnormal mitochondrial crista morphology J:113016
abnormal mitochondrial morphology J:113016
abnormal mitochondrial physiology J:113016
abnormal myocardial fiber morphology J:113016
abnormal respiratory electron transport chain J:113016
abnormal skeletal muscle fiber morphology J:113016
cardiac hypertrophy J:113016
decreased cardiac muscle contractility J:113016
decreased catalase activity J:113016
decreased skeletal muscle mass J:113016
dilated cardiomyopathy J:113016
enlarged heart J:113016
increased circulating lactate level J:113016
increased mitochondrial number J:113016
increased myocardial fiber size J:113016
increased skeletal muscle fiber diameter J:113016
lethargy J:113016
muscle degeneration J:113016
muscular atrophy J:113016
oxidative stress J:113016
weight loss J:113016
Aifm1tm2Pngr/Y
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB/N 		embryonic growth retardation J:113016
embryonic lethality during organogenesis, complete penetrance J:113016
Gt(ROSA)26Sortm8(Aifm1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA 		normal mortality/aging J:194078
Gt(ROSA)26Sortm9(Aifm1*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA 		normal mortality/aging J:194078
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory