Pla2g10 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pla2g10
phospholipase A2, group X
MGI:1347522

28 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pla2g10^Gt712Lex/Pla2g10^Gt712Lex involves: 129S5/SvEvBrd * C57BL/6J	abnormal interleukin level	J:125607
	abnormal prostaglandin level	J:125607
	decreased CD4-positive, alpha-beta T cell number	J:125607
	decreased CD8-positive, alpha-beta T cell number	J:125607
	decreased eosinophil cell number	J:125607
	decreased IgE level	J:125607
	decreased inflammatory response	J:125607
	decreased T cell number	J:125607
Pla2g10^{tm1a(EUCOMM)Hmgu}/Pla2g10⁺ C57BL/6N-Pla2g10^{tm1a(EUCOMM)Hmgu}/Ieg	increased body weight	J:165965
Pla2g10^{tm1b(EUCOMM)Hmgu}/Pla2g10^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pla2g10^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal QT variability	J:211773
	cardiovascular system phenotype	J:211773
	cataract	J:211773
	decreased grip strength	J:211773
	decreased heart rate	J:211773
	increased heart rate variability	J:211773
	prolonged QT interval	J:211773
	prolonged RR interval	J:211773
Pla2g10^tm1Itl/Pla2g10^tm1Itl involves: C57BL/6NTac	hypersecretion of corticosterone	J:164545
Pla2g10^tm1Itl/Pla2g10^tm1Itl involves: C57BL/6NTac	increased circulating corticosterone level	J:164545
Pla2g10^tm1Kiku/Pla2g10^tm1Kiku B6.129P2-Pla2g10^tm1Kiku	abnormal cardiac muscle contractility	J:155082
	abnormal neutrophil physiology	J:155082
	abnormal response of heart to induced stress	J:155082
	decreased myocardial infarct size	J:155082
	decreased neutrophil cell number	J:155082
	normal immune system phenotype	J:197334
	impaired neutrophil chemotaxis	J:155082
Pla2g10^tm1Kiku/Pla2g10^tm1Kiku involves: 129P2/OlaHsd	abnormal male reproductive system physiology	J:161462

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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