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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
MGI:1346882
11 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Map4k1m1Anu/Map4k1m1Anu
C57BL/6NCrlAnu-Map4k1m1Anu
normal immune system phenotype J:104190
Map4k1tm1Ssaw/Map4k1tm1Ssaw
B6.Cg-Map4k1tm1Ssaw
abnormal dendritic cell antigen presentation J:150295
abnormal dendritic cell physiology J:150295
increased interleukin-1 beta secretion J:150295
increased interleukin-6 secretion J:150295
increased interleukin-12 secretion J:150295
increased tumor necrosis factor secretion J:150295
Map4k1tm1Tht/Map4k1tm1Tht
B6.129S7-Map4k1tm1Tht
increased susceptibility to experimental autoimmune encephalomyelitis J:116613
Map4k1tm1Tht/Map4k1tm1Tht
involves: 129S7/SvEvBrd
abnormal cytokine secretion J:116613
abnormal humoral immune response J:116613
increased T cell proliferation J:116613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory