Map4k1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
MGI:1346882

11 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map4k1^m1Anu/Map4k1^m1Anu C57BL/6NCrlAnu-Map4k1^m1Anu	normal immune system phenotype	J:104190
Map4k1^tm1Ssaw/Map4k1^tm1Ssaw B6.Cg-Map4k1^tm1Ssaw	abnormal dendritic cell antigen presentation	J:150295
	abnormal dendritic cell physiology	J:150295
	increased interleukin-1 beta secretion	J:150295
	increased interleukin-6 secretion	J:150295
	increased interleukin-12 secretion	J:150295
	increased tumor necrosis factor secretion	J:150295
Map4k1^tm1Tht/Map4k1^tm1Tht B6.129S7-Map4k1^tm1Tht	increased susceptibility to experimental autoimmune encephalomyelitis	J:116613
Map4k1^tm1Tht/Map4k1^tm1Tht involves: 129S7/SvEvBrd	abnormal cytokine secretion	J:116613
	abnormal humoral immune response	J:116613
	increased T cell proliferation	J:116613

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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