About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k12
mitogen-activated protein kinase kinase kinase 12
MGI:1346881
28 phenotypes from 8 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg
involves: 129P2/OlaHsd * C57BL/6 		absent anterior commissure J:125702
Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg
involves: 129P2/OlaHsd * C57BL/6J 		slow Wallerian degeneration J:188476
Map3k12tm1.1Adia/Map3k12tm1.1Adia
involves: C57BL/6 * C57BL/6J * SJL 		slow Wallerian degeneration J:188476
Map3k12tm1.1Lewc/Map3k12tm1.1Lewc
Not Specified 		abnormal dorsal root ganglion morphology J:176956
abnormal neuron differentiation J:176956
decreased neuron apoptosis J:176956
Map3k12tm1.1Lewc/Map3k12tm1.1Lewc
Tg(Mnx1-GFP)1Slp/0
Not Specified 		increased motor neuron number J:176956
normal nervous system phenotype J:176956
Map3k12tm1.2Adia/Map3k12tm1.2Adia
involves: C57BL/6 * C57BL/6J * SJL 		perinatal lethality J:188476
slow Wallerian degeneration J:188476
Map3k12tm1b(EUCOMM)Hmgu/Map3k12+
C57BL/6N-Map3k12tm1b(EUCOMM)Hmgu/Bay 		increased heart left ventricle size J:211773
thick ventricular wall J:211773
Map3k12tm1b(EUCOMM)Hmgu/Map3k12tm1b(EUCOMM)Hmgu
C57BL/6N-Map3k12tm1b(EUCOMM)Hmgu/Bay 		preweaning lethality, complete penetrance J:211773
Map3k12tm1Lbh/Map3k12tm1Lbh
Not Specified 		abnormal axon extension J:236918
abnormal cell physiology J:236918
Map3k12tm1Lewc/Map3k12tm1Lewc
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * CBA 		decreased retina ganglion cell number J:196076
Map3k12tm1Shir/Map3k12tm1Shir
B6.Cg-Mapk12tm1Shir 		abnormal anterior commissure morphology J:115575
abnormal anterior commissure pars anterior morphology J:115575
abnormal anterior commissure pars posterior morphology J:115575
abnormal brain internal capsule morphology J:115575
abnormal brain morphology J:115575
abnormal brain white matter morphology J:115575
abnormal cerebral cortex morphology J:115575
abnormal cingulum morphology J:115575
abnormal enzyme/coenzyme activity J:115575
abnormal neuronal migration J:115575
abnormal olfactory bulb morphology J:115575
abnormal olfactory tract morphology J:115575
decreased corpus callosum size J:115575
postnatal lethality, complete penetrance J:115575
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory