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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Bace1
beta-site APP cleaving enzyme 1
MGI:1346542
38 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Bace1tm1.1Slr/Bace1tm1.1Slr
involves: 129P2/OlaHsd * C57BL/6 * CBA
no abnormal phenotype detected J:77414
Bace1tm1Bux/Bace1tm1Bux
involves: 129S5/SvEvBrd * C57BL/6
no abnormal phenotype detected J:89370
Bace1tm1Cdi/Bace1tm1Cdi
involves: 129P2/OlaHsd * C57BL/6J
abnormal anxiety-related response J:86936
abnormal muscle physiology J:86936
decreased exploration in new environment J:86936
improved righting response J:86936
Bace1tm1Nn/Bace1tm1Nn
Not Specified
abnormal cell physiology J:100272
Bace1tm1Pcw/Bace1tm1Pcw
involves: 129S1/Sv * 129X1/SvJ
abnormal myelin sheath morphology J:116162
abnormal myelination J:116162
decreased grip strength J:116162
decreased thermal nociceptive threshold J:116162
Bace1tm1Pcw/Bace1tm1Pcw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal dendritic spine morphology J:133643
abnormal dishabituation J:133643
abnormal locomotor activation J:123534
abnormal long-term depression J:123534
abnormal response to novel object J:133643
abnormal spatial learning J:123534
abnormal spatial reference memory J:123534
abnormal spatial working memory J:123534, J:133643
abnormal startle reflex J:133643
decreased anxiety-related response J:123534
decreased prepulse inhibition J:133643
enhanced behavioral response to xenobiotic J:133643
enhanced paired-pulse facilitation J:123534
impaired passive avoidance behavior J:133643
Bace1tm1Psa/Bace1+
involves: 129S2/SvPas * C57BL/6
decreased muscle spindle number J:199150
Bace1tm1Psa/Bace1tm1Psa
either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CD-1)
abnormal channel response J:100925
abnormal nervous system physiology J:100925
cachexia J:100925
decreased anxiety-related response J:100925
decreased body weight J:100925
hyperactivity J:100925
postnatal growth retardation J:100925
postnatal lethality, incomplete penetrance J:100925
Bace1tm1Psa/Bace1tm1Psa
involves: 129S2/SvPas * C57BL/6
abnormal gait J:199150
abnormal muscle spindle morphology J:199150
decreased muscle spindle number J:199150
demyelination J:199150
impaired coordination J:199150
Bace1tm1Psa/Bace1tm1Psa
involves: 129S2/SvPas * C57BL/6J
normal pigmentation phenotype J:197977
Bace1tm1Vas/Bace1tm1Vas
involves: 129S1/Sv * 129X1/SvJ
no abnormal phenotype detected J:67736
Bace1tm2Psa/Bace1tm2Psa
involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6
decreased anxiety-related response J:100925
increased locomotor activity J:100925
postnatal lethality, incomplete penetrance J:100925
Bace1tm2Slr/Bace1tm2Slr
involves: 129S5/SvEvBrd * C57BL/6
no abnormal phenotype detected J:77414

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory