Lgr5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgr5
leucine rich repeat containing G protein coupled receptor 5
MGI:1341817

21 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lgr5^{em1(IMPC)Kmpc}/Lgr5⁺ C57BL/6NTac-Lgr5^{em1(IMPC)Kmpc}/Kmpc	increased CD4-negative, CD25-positive NK T cell number	J:211773
	increased CD8-positive, CD25-positive alpha-beta T cell number	J:211773
	increased CD11b-high dendritic cell number	J:211773
	increased circulating bilirubin level	J:211773
	increased grip strength	J:211773
	no spontaneous movement	J:211773
Lgr5^{em1(IMPC)Kmpc}/Lgr5^{em1(IMPC)Kmpc} C57BL/6NTac-Lgr5^{em1(IMPC)Kmpc}/Kmpc	cleft palate	J:211773
	no spontaneous movement	J:211773
	preweaning lethality, complete penetrance	J:211773
Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal intestinal epithelium physiology	J:285672
	normal digestive/alimentary phenotype	J:285672
Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} involves: C57BL/6	normal digestive/alimentary phenotype	J:212415
	normal integument phenotype	J:212415
	perinatal lethality, complete penetrance	J:212415
	normal renal/urinary system phenotype	J:212415
Lgr5^tm1Ah/Lgr5^tm1Ah involves: 129S5/SvEvBrd	abnormal suckling behavior	J:127123
	abnormal tongue morphology	J:127123
	cyanosis	J:127123
	distended abdomen	J:127123
	neonatal lethality, complete penetrance	J:127123
	respiratory failure	J:127123
Lgr5^tm1Ah/Lgr5^tm1Ah involves: 129S5/SvEvBrd * C57BL/6	abnormal suckling behavior	J:94196
	absent gastric milk in neonates	J:94196
	cyanosis	J:94196
	distended abdomen	J:94196
	neonatal lethality, complete penetrance	J:94196
	respiratory failure	J:94196
	tongue ankylosis	J:94196
Lgr5^tm2.1Cle/Lgr5^tm2.1Cle Tg(Cyp1a1-cre)1Dwi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	normal digestive/alimentary phenotype	J:174842

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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