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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lhx6
LIM homeobox protein 6
MGI:1306803
19 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Lhx6tm1(cre/ERT2)Zjh/Lhx6+
involves: C57BL/6
no abnormal phenotype detected J:151755
Lhx6tm1b(KOMP)Wtsi/Lhx6+
C57BL/6N-Lhx6tm1b(KOMP)Wtsi/Ucd
decreased circulating alanine transaminase level J:211773
increased circulating HDL cholesterol level J:211773
Lhx6tm1b(KOMP)Wtsi/Lhx6tm1b(KOMP)Wtsi
C57BL/6N-Lhx6tm1b(KOMP)Wtsi/Ucd
preweaning lethality, incomplete penetrance J:211773
Lhx6tm1Vpa/Lhx6tm1Vpa
involves: 129P2/OlaHsd * C57BL/6
no abnormal phenotype detected J:198547
Lhx6tm1Vpa/Lhx6tm2Vpa
involves: 129P2/OlaHsd * C57BL/6
abnormal brain interneuron morphology J:198547
abnormal miniature inhibitory postsynaptic currents J:198547
abnormal neuron differentiation J:198547
abnormal spike wave discharge J:198547
decreased neuron number J:198547
environmentally induced seizures J:198547
increased susceptibility to pharmacologically induced seizures J:198547
normal nervous system phenotype J:198547
tonic-clonic seizures J:198547
Lhx6tm2Vpa/Lhx6tm2Vpa
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
abnormal brain interneuron morphology J:119476
abnormal cerebral cortex morphology J:119476
abnormal hippocampus morphology J:119476
abnormal neuronal migration J:119476
postnatal lethality, complete penetrance J:119476
weakness J:119476
Lhx6tm2Vpa/Lhx6tm2Vpa
involves: 129P2/OlaHsd * C57BL/6
abnormal brain interneuron morphology J:198547
abnormal inhibitory postsynaptic currents J:198547
decreased neuron number J:198547

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2018
MGI 6.11
The Jackson Laboratory