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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cdk6
cyclin-dependent kinase 6
MGI:1277162
47 phenotypes from 7 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdk6tm1.1Phin/Cdk6tm1.1Phin
involves: 129S4/SvJae * C57BL/6
normal immune system phenotype J:144975
Cdk6tm1b(EUCOMM)Wtsi/Cdk6tm1b(EUCOMM)Wtsi
C57BL/6N-Cdk6tm1b(EUCOMM)Wtsi/Tcp
abnormal eye morphology J:211773
small superior vagus ganglion J:211773
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal definitive hematopoiesis J:92529
abnormal erythrocyte morphology J:92529
abnormal hematopoietic system morphology/development J:92529
abnormal spleen morphology J:92529
abnormal spleen red pulp morphology J:92529
abnormal thymus morphology J:92529
decreased body weight J:92529
decreased erythrocyte cell number J:92529
decreased leukocyte cell number J:92529
decreased mature ovarian follicle number J:92529
decreased megakaryocyte cell number J:92529
decreased T cell proliferation J:92529
increased mean corpuscular hemoglobin concentration J:92529
increased mean corpuscular volume J:92529
increased single-positive T cell number J:92529
reduced female fertility J:92529
small spleen J:92529
spleen hypoplasia J:92529
thymus cortex atrophy J:92529
thymus hypoplasia J:92529
Cdk6tm1Phin/Cdk6tm1Phin
involves: 129S4/SvJae
abnormal lymphopoiesis J:144975
abnormal T cell differentiation J:144975
abnormal thymocyte activation J:144975
decreased CD8-positive, alpha-beta T cell number J:144975
decreased double-negative T cell number J:144975
decreased double-positive T cell number J:144975
decreased thymocyte apoptosis J:144975
decreased thymocyte number J:144975
thymus atrophy J:144975
thymus hypoplasia J:144975
Cdk6tm1Phin/Cdk6tm1Phin
involves: 129S4/SvJae * C57BL/6
abnormal hematopoietic stem cell physiology J:174697
decreased DN1 thymic pro-T cell number J:174697
decreased DN2 thymocyte number J:174697
decreased double-positive T cell number J:174697
decreased hematopoietic stem cell number J:174697
normal immune system phenotype J:174697
increased CD4-positive, alpha beta T cell number J:174697
increased CD8-positive, alpha-beta T cell number J:174697
increased DN3 thymocyte number J:174697
Cdk6tm2.1Phin/Cdk6tm2.1Phin
involves: 129 * C57BL/6 * FVB/N
abnormal hematopoietic stem cell physiology J:174697
abnormal T cell differentiation J:174697
decreased DN1 thymic pro-T cell number J:174697
decreased DN2 thymocyte number J:174697
decreased DN4 thymocyte number J:174697
decreased double-positive T cell number J:174697
decreased hematopoietic stem cell number J:174697
decreased thymocyte number J:174697
increased CD4-positive, alpha beta T cell number J:174697
increased CD8-positive, alpha-beta T cell number J:174697
increased DN3 thymocyte number J:174697
increased double-negative T cell number J:174697
small thymus J:174697
Cdk6tm3.1Phin/Cdk6tm3.1Phin
involves: 129 * C57BL/6 * FVB/N
abnormal hematopoietic stem cell physiology J:174697
abnormal T cell differentiation J:174697
enlarged thymus J:174697
normal immune system phenotype J:174697
increased CD4-positive, alpha beta T cell number J:174697
increased DN1 thymic pro-T cell number J:174697
increased hematopoietic stem cell number J:174697
increased T cell apoptosis J:174697
increased thymocyte number J:174697
Cdk6tm4.1Phin/Cdk6tm4.1Phin
involves: 129 * C57BL/6 * FVB/N
abnormal hematopoietic stem cell physiology J:174697
abnormal T cell differentiation J:174697
decreased DN1 thymic pro-T cell number J:174697
decreased DN2 thymocyte number J:174697
decreased DN4 thymocyte number J:174697
decreased double-positive T cell number J:174697
decreased thymocyte number J:174697
normal immune system phenotype J:174697
increased CD4-positive, alpha beta T cell number J:174697
increased CD8-positive, alpha-beta T cell number J:174697
increased DN3 thymocyte number J:174697
increased hematopoietic stem cell number J:174697
small thymus J:174697

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory