35 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdh23tm1.1Ugds/Cdh23tm1.1Ugds Myo15atm1.1(cre)Ugds/Myo15a+ involves: 129S1/SvImJ * C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:171218
	abnormal hearing electrophysiology	J:171218
	abnormal inner hair cell stereociliary bundle morphology	J:171218
	abnormal outer hair cell stereociliary bundle morphology	J:171218
	absent cochlear microphonics	J:171218
	absent distortion product otoacoustic emissions	J:171218
	decreased inner hair cell stereocilia number	J:171218
	decreased outer hair cell stereocilia number	J:171218
	impaired hearing	J:171218
	increased or absent threshold for auditory brainstem response	J:171218
	short inner hair cell stereocilia	J:171218
	short outer hair cell stereocilia	J:171218
Clrn1tm1.1Ugpa/Clrn1tm1.1Ugpa Myo15atm1.1(cre)Ugds/Myo15a+ involves: 129S1/SvImJ * C57BL/6N	abnormal cochlear IHC afferent innervation pattern	J:265318
	abnormal cochlear inner hair cell physiology	J:265318
	abnormal cochlear nerve compound action potential	J:265318
	abnormal cochlear nerve fiber response	J:265318
	abnormal cochlear nerve morphology	J:265318
	abnormal inner hair cell stereociliary bundle morphology	J:265318
	abnormal outer hair cell stereociliary bundle morphology	J:265318
	abnormal ribbon synapse morphology	J:265318
	abnormal synapse morphology	J:265318
	abnormal synaptic vesicle exocytosis	J:265318
	cochlear inner hair cell degeneration	J:265318
	cochlear outer hair cell degeneration	J:265318
	deafness	J:265318
	increased or absent distortion product otoacoustic emission threshold	J:265318
	increased or absent threshold for auditory brainstem response	J:265318
	sensorineural hearing loss	J:265318
Myo15ash2/Myo15a+ Myo6sv/Myo6+ involves: B10.HA/(33NX)Sn	increased susceptibility to age-related hearing loss	J:86379
Myo15ash2/Myo15ash2 Myo6sv/Myo6sv involves: B10.HA/(33NX)Sn	abnormal cochlear hair cell stereociliary bundle morphology	J:86379
	abnormal organ of Corti morphology	J:86379
	decreased body size	J:86379
	short cochlear hair cell stereocilia	J:86379
Myo15atm1.1(cre)Ugds/Myo15a+ Ush1gtm1.1Ugds/Ush1gtm1.1Ugds involves: 129S1/SvImJ * C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:171218
	abnormal hair cell mechanoelectric transduction	J:171218
	abnormal hair cell physiology	J:171218
	abnormal hearing electrophysiology	J:171218
	abnormal inner hair cell stereociliary bundle morphology	J:171218
	abnormal outer hair cell stereociliary bundle morphology	J:171218
	abnormal vestibular system physiology	J:171218
	absent cochlear microphonics	J:171218
	absent distortion product otoacoustic emissions	J:171218
	circling	J:171218
	deafness	J:171218
	decreased inner hair cell stereocilia number	J:171218
	decreased outer hair cell stereocilia number	J:171218
	increased or absent threshold for auditory brainstem response	J:171218
	short inner hair cell stereocilia	J:171218
	short outer hair cell stereocilia	J:171218
Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds Myo15atm1.1(cre)Ugds/Myo15a+ involves: 129S1/SvImJ * C57BL/6J	abnormal auditory brainstem response	J:209275
	abnormal cochlear hair bundle tip links morphology	J:209275
	abnormal cochlear nerve compound action potential	J:209275
	abnormal hair cell mechanoelectric transduction	J:209275
	abnormal outer hair cell stereociliary bundle morphology	J:209275
	deafness	J:209275
	decreased inner hair cell stereocilia number	J:209275
	decreased outer hair cell stereocilia number	J:209275
	increased or absent threshold for auditory brainstem response	J:209275
	short inner hair cell stereocilia	J:209275
	short outer hair cell stereocilia	J:209275