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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Wrn
Werner syndrome RecQ like helicase
MGI:109635
31 phenotypes from 3 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Wrnb2b3121.1Clo/Wrnb2b3121.1Clo
C57BL/6J-Wrnb2b3121.1Clo
abnormal cardiovascular development J:175213
bicuspid aortic valve J:175213
bicuspid pulmonary valve J:175213
cleft palate J:175213
enlarged adrenal glands J:175213
thymus hypoplasia J:175213
Wrntm1Led/Wrn+
involves: 129S6/SvEvTac * Black Swiss
cardiac interstitial fibrosis J:106446
Wrntm1Led/Wrntm1Led
B6.129S6(BKSW)-Wrntm1Led
aortic valve stenosis J:106446
cardiac interstitial fibrosis J:106446
decreased systemic arterial diastolic blood pressure J:106446
hyperglycemia J:106446
hyperlipidemia J:106446
increased abdominal adipose tissue amount J:106446
increased cellular sensitivity to oxidative stress J:106446
increased circulating cholesterol level J:106446
increased circulating hyaluronic acid level J:106446
increased circulating insulin level J:106446
increased circulating triglyceride level J:106446
increased inguinal fat pad weight J:106446
increased left ventricle systolic pressure J:106446
increased retroperitoneal fat pad weight J:106446
increased susceptibility to age related obesity J:106446
insulin resistance J:106446
oxidative stress J:106446
Wrntm1Led/Wrntm1Led
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * NIH Black Swiss)
increased tumor incidence J:48424
preweaning lethality, incomplete penetrance J:48424
Wrntm1Led/Wrntm1Led
involves: 129S6/SvEvTac * Black Swiss
abnormal thrombosis J:106446
cardiac interstitial fibrosis J:106446
heart inflammation J:106446
increased susceptibility to infection J:106446
increased tumor incidence J:106446
Wrntm1Lgu/Wrntm1Lgu
B6J.Cg-Wrntm1Lgu
decreased bone volume J:213181
increased osteoclast cell number J:213181
Wrntm1Lgu/Wrntm1Lgu
involves: BALB/c
abnormal cell physiology J:61567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory