Lama4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lama4
laminin, alpha 4
MGI:109321

16 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lama2^dy-2J/Lama2^dy-2J Lama4^tm1Ktry/Lama4^tm1Ktry involves: 129X1/SvJ * C57BL/6 * WK/ReJ	abnormal basal lamina morphology	J:98086
	abnormal motor capabilities/coordination/movement	J:98086
	abnormal myelination	J:98086
	decreased body size	J:98086
	decreased Schwann cell number	J:98086
	limb grasping	J:98086
	normal nervous system phenotype	J:98086
	postnatal lethality, complete penetrance	J:98086
	tremors	J:98086
Lama2^dy-2J/Lama2^dy-2J Lama4^tm1Ktry/Lama4^tm1Ktry Tg(ACTB-Lama5)1Jhm/0 involves: 129X1/SvJ * C57BL/6 * WK/ReJ	abnormal basal lamina morphology	J:98086
	normal behavior/neurological phenotype	J:98086
	normal nervous system phenotype	J:98086
Lama2^dy/Lama2^dy Lama4^tm1Ktry/Lama4^tm1Ktry involves: 129P1/ReJ * 129X1/SvJ	abnormal rostral migratory stream morphology	J:120076
Lama2^tm1Stk/Lama2^tm1Stk Lama4^tm1Ktry/Lama4^tm1Ktry involves: 129P2/OlaHsd * 129X1/SvJ	abnormal axon radial sorting	J:98086
	decreased Schwann cell number	J:98086
	postnatal lethality, complete penetrance	J:98086
Lama4^tm1Ktry/Lama4^tm1Ktry Lama5^tm2Jhm/Lama5^tm2Jhm Tg(ACTA1-cre)1Mll/0 involves: 129S1/Sv * 129X1/SvJ	abnormal innervation pattern to muscle	J:142595
	abnormal neuromuscular synapse morphology	J:142595
	decreased body size	J:142595
	premature death	J:142595
	weakness	J:142595

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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