Fgf14 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fgf14
fibroblast growth factor 14
MGI:109189

27 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fgf14^{em1(IMPC)Ccpcz}/Fgf14^{em1(IMPC)Ccpcz} C57BL/6N-Fgf14^{em1(IMPC)Ccpcz}/Ccpcz	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spine curvature	J:211773
	abnormal spleen morphology	J:211773
	abnormal thyroid gland morphology	J:211773
	decreased body weight	J:211773
	decreased grip strength	J:211773
	enlarged thyroid gland	J:211773
	increased circulating alkaline phosphatase level	J:211773
	kyphosis	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Fgf14^tm1Dor/Fgf14^tm1Dor 129S6/SvEvTac-Fgf14^tm1Dor	abnormal gait	J:77806
	abnormal locomotor activation	J:77806
	abnormal motor capabilities/coordination/movement	J:77806
	abnormal nervous system physiology	J:77806
	abnormal posture	J:77806
	ataxia	J:77806
	decreased body weight	J:77806
	decreased grip strength	J:77806
	impaired balance	J:77806
	impaired coordination	J:77806
	increased susceptibility to pharmacologically induced seizures	J:77806
	limb grasping	J:77806
Fgf14^tm1Dor/Fgf14^tm1Dor B6.129S6-Fgf14^tm1Dor	abnormal gait	J:77806
	abnormal locomotor activation	J:77806
	abnormal motor capabilities/coordination/movement	J:77806
	abnormal nervous system physiology	J:77806
	abnormal posture	J:77806
	ataxia	J:77806, J:134733
	decreased body weight	J:77806
	decreased grip strength	J:77806, J:134733
	impaired balance	J:77806
	impaired coordination	J:77806, J:134733
	impaired spatial learning	J:134733
	increased locomotor activity	J:134733
	increased susceptibility to pharmacologically induced seizures	J:77806
	limb grasping	J:77806
	reduced long-term potentiation	J:134733
Fgf14^tm1Dor/Fgf14^tm1Dor involves: 129S6/SvEvTac * C57BL/6	abnormal CNS synaptic transmission	J:128732
	abnormal nervous system electrophysiology	J:144561
	decreased grip strength	J:128732
	weakness	J:128732

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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