Nbr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nbr1
NBR1, autophagy cargo receptor
MGI:108498

21 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nbr1^tm1.1Jmos/Nbr1^tm1.1Jmos Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ involves: 129X1/SvJ * C57BL/6J	abnormal T-helper 1 cell differentiation	J:165438
	abnormal T-helper 2 cell differentiation	J:165438
	decreased inflammatory response	J:165438
	decreased interferon-gamma secretion	J:165438
	decreased interleukin-4 secretion	J:165438
	decreased interleukin-5 secretion	J:165438
	decreased interleukin-13 secretion	J:165438
Nbr1^{tm1b(KOMP)Wtsi}/Nbr1^{tm1b(KOMP)Wtsi} C57BL/6N-Nbr1^{tm1b(KOMP)Wtsi}/H	impaired glucose tolerance	J:211773
Nbr1^tm1Whca/Nbr1^tm1Whca B6.129P2-Nbr1^tm1Whca	abnormal bone structure	J:162412
	abnormal osteoblast differentiation	J:162412
	abnormal osteoclast physiology	J:162412
	decreased bone trabecular spacing	J:162412
	increased bone mass	J:162412
	increased bone mineral density	J:162412
	increased bone mineral density of femur	J:162412
	increased bone ossification	J:162412
	increased bone trabecula number	J:162412
	increased diameter of femur	J:162412
	increased diameter of humerus	J:162412
	increased osteoid thickness	J:162412
	increased trabecular bone volume	J:162412

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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