Nbr1tm1Whca
Targeted Allele Detail
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Symbol: |
Nbr1tm1Whca |
Name: |
NBR1, autophagy cargo receptor; targeted mutation 1, Caroline A Whitehouse |
MGI ID: |
MGI:4819974 |
Synonyms: |
Nbr1tr |
Gene: |
Nbr1 Location: Chr11:101442975-101472777 bp, + strand Genetic Position: Chr11, 65.36 cM
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Alliance: |
Nbr1tm1Whca page
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Germline Transmission: |
Earliest citation of germline transmission:
J:162412
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Parent Cell Line: |
E14.2 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neo cassette replaced exons 6, 7 and part of the exon 8 by homologous recombination, introducing a stop at codon 135. Protein extracts from homozygous osteoblasts showed loss of the endogenous full-length protein and stable expression of truncated protein at equivalent levels.
(J:162412)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nbr1 Mutation: |
74 strains or lines available
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Original: |
J:162412 Whitehouse CA, et al., Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity. (Correction). Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12913-8 |
All: |
1 reference(s) |
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