Ripk1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ripk1
receptor (TNFRSF)-interacting serine-threonine kinase 1
MGI:108212

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	lethality throughout fetal growth and development, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	decreased body size	J:182515
	postnatal lethality, incomplete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	lethality throughout fetal growth and development, complete penetrance	J:182515
Casp8^em1Hbz/Casp8^em1Hbz Ripk1^em1Hbz/Ripk1^em1Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased leukocyte cell number	J:342732
	decreased lymphocyte cell number	J:342732
	decreased mature B cell number	J:342732
	decreased T cell number	J:342732
Casp8^em1Hbz/Casp8^em1Hbz Ripk1^em4Hbz/Ripk1^em4Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased body size	J:342732
	preweaning lethality, complete penetrance	J:342732
	scaly skin	J:342732
	skin lesions	J:342732
Ripk1^tm1.1Vmd/Ripk1⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd involves: C57BL/6N	decreased hematopoietic cell number	J:209137
	decreased liver glycogen level	J:209137
	pallor	J:209137
Ripk1^tm1.1Vmd/Ripk1^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd involves: C57BL/6N	abnormal intestine morphology	J:209137
	neonatal lethality	J:209137
Ripk1^tm1Geno/Ripk1^tm1Geno Ripk3^tm2Vmd/Ripk3^tm2Vmd involves: C57BL/6 * C57BL/6N	embryonic lethality	J:209137

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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