Rock2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rock2
Rho-associated coiled-coil containing protein kinase 2
MGI:107926

35 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rock2^{Gt(OST440776)Lex}/Rock2^{Gt(OST440776)Lex} involves: 129S5/SvEvBrd * C57BL/6J	decreased body size	J:186058
	decreased body weight	J:186058
	decreased eye anterior chamber depth	J:186058
	lethality, incomplete penetrance	J:186058
	ocular hypotension	J:186058
	retina degeneration	J:186058
	retina neovascularization	J:186058
Rock2^tm1.1Itl/Rock2⁺ Tg(Tagln-cre)1Her/0 B6.Cg-Rock2^tm1.1Itl Tg(Tagln-cre)1Her	abnormal cytokine secretion	J:222206
	abnormal vascular smooth muscle physiology	J:222206
	decreased susceptibility to hypertension	J:222206
	decreased vascular smooth muscle cell proliferation	J:222206
Rock2^tm1.1Itl/Rock2^tm1.1Itl Tg(Tagln-cre)1Her/0 involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL	embryonic lethality, complete penetrance	J:222206
Rock2^tm1.1Liao/Rock2⁺ involves: C57BL/6	normal cardiovascular system phenotype	J:135152
Rock2^tm1Sna/Rock2^tm1Sna involves: 129X1/SvJ * C57BL/6	abnormal extraembryonic tissue morphology	J:84386
	abnormal placenta morphology	J:84386
	decreased body size	J:84386
	hemorrhage	J:84386
	premature death	J:84386
	prenatal lethality, incomplete penetrance	J:84386
Rock2^tm1Zpj/Rock2⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal cardiovascular system morphology	J:224630
	abnormal cardiovascular system physiology	J:224630
	abnormal circulating cholesterol level	J:224630
	decreased circulating free fatty acids level	J:224630
	decreased susceptibility to diet-induced obesity	J:224630
	normal growth/size/body region phenotype	J:224630
	normal homeostasis/metabolism phenotype	J:224630
	improved glucose tolerance	J:224630
Rock2^tm1Zpj/Rock2^tm1Zpj involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal actin cytoskeleton morphology	J:225274
	abnormal excitatory postsynaptic potential	J:225274
	abnormal synapse morphology	J:225274
	decreased paired-pulse facilitation	J:225274
	increased dendritic spine length	J:225274
	normal nervous system phenotype	J:225274
	reduced long-term potentiation	J:225274
Rock2^tm2Liao/Rock2^tm2Liao Tg(Myh6-cre)2182Mds/? involves: 129/Sv * C57BL/6	abnormal heart morphology	J:196433
	abnormal heart size	J:196433
	normal cardiovascular system phenotype	J:196433

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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