Dctn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dctn1
dynactin 1
MGI:107745

22 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dctn1^tm1.1Cai/Dctn1^tm1.1Cai involves: 129X1/SvJ * C57BL/6 * FVB/N	embryonic growth arrest	J:129269
	embryonic lethality, complete penetrance	J:129269
	increased apoptosis	J:129269
Dctn1^{tm1a(EUCOMM)Wtsi}/Dctn1⁺ C57BL/6N-Dctn1^{tm1a(EUCOMM)Wtsi}/Wtsi	increased circulating creatinine level	J:211773
Dctn1^{tm1a(EUCOMM)Wtsi}/Dctn1^{tm1a(EUCOMM)Wtsi} C57BL/6N-Dctn1^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Dctn1^tm1Cai/Dctn1⁺ involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal neuromuscular synapse morphology	J:129269
	motor neuron degeneration	J:129269
	short stride length	J:129269
Dctn1^tm1Cai/Dctn1^tm1Cai involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal gastrulation	J:129269
	abnormal neural tube morphology	J:129269
	absent somites	J:129269
	embryonic growth arrest	J:129269
	embryonic lethality, complete penetrance	J:129269
	increased apoptosis	J:129269
Dctn1^tm2.1Cai/Dctn1^tm2.1Cai Tg(Thy1-cre)1Vln/? involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N	abnormal motor neuron morphology	J:264431
	abnormal neuromuscular synapse morphology	J:264431
	astrocytosis	J:264431
	decreased gastrocnemius weight	J:264431
	decreased motor neuron number	J:264431
	decreased vertical activity	J:264431
	impaired coordination	J:264431
	increased susceptibility to neuronal excitotoxicity	J:264431
	limb grasping	J:264431
	lysosomal protein accumulation	J:264431
	microgliosis	J:264431
	motor neuron degeneration	J:264431
	skeletal muscle atrophy	J:264431

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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