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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Aurkb
aurora kinase B
MGI:107168
28 phenotypes from 5 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Aurkbtm1.1Mama/Aurkbtm1.1Mama
involves: 129/Sv * C57BL/6 * CD-1 * SJL
abnormal cell morphology J:173575
abnormal cell nucleus morphology J:173575
abnormal mitosis J:173575
abnormal mitotic spindle morphology J:173575
increased cell nucleus count J:173575
increased fibroblast apoptosis J:173575
polyploidy J:173575
Aurkbtm1.2Mama/Aurkb+
involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL
increased adenocarcinoma incidence J:173575
increased liver adenocarcinoma incidence J:173575
increased skin papilloma incidence J:173575
increased tumor incidence J:173575
oligozoospermia J:173575
premature death J:173575
Aurkbtm1.2Mama/Aurkbtm2.2Mama
involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL
abnormal ectoplacental cone morphology J:173575
abnormal embryonic tissue morphology J:173575
abnormal inner cell mass morphology J:173575
abnormal mitosis J:173575
abnormal mitotic spindle morphology J:173575
abnormal trophoblast giant cell morphology J:173575
decreased embryo size J:173575
decreased trophoblast giant cell number J:173575
edema J:173575
embryonic lethality J:173575
hemorrhage J:173575
increased embryonic tissue cell apoptosis J:173575
polyploidy J:173575
Tg(B4galt1-Aurkb)1Saco/0
involves: 129/Sv * C57BL/6J * SJL
no abnormal phenotype detected J:142947
Tg(B4galt1-Aurkb*K111R*L323I)1Saco/0
involves: 129/Sv * C57BL/6J * SJL
abnormal male meiosis J:142947
abnormal spermatid morphology J:142947
abnormal spermatogenesis J:142947
oligozoospermia J:142947
reduced male fertility J:142947

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory