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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Clcn2
chloride channel, voltage-sensitive 2
MGI:105061
48 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Clcn2nmf240/Clcn2nmf240
C57BL/6J-Clcn2nmf240/J
abnormal cone electrophysiology J:160207
abnormal eye electrophysiology J:160207
abnormal photoreceptor outer segment morphology J:160207
abnormal retinal photoreceptor layer morphology J:160207
abnormal retinal pigment epithelium morphology J:160207
abnormal rod electrophysiology J:160207
abnormal spermatogenesis J:160207
abnormal spermiogenesis J:82238
axon degeneration J:82238
azoospermia J:160207
brain vacuoles J:160207
neurodegeneration J:82238
retinal degeneration J:82238, J:160207
retinal photoreceptor degeneration J:160207
thin retinal outer nuclear layer J:160207
Clcn2tm1Mlv/Clcn2tm1Mlv
involves: C57BL/6
abnormal male germ cell morphology J:77673
abnormal salivary gland physiology J:77673
abnormal Sertoli cell morphology J:77673
abnormal testis morphology J:77673
azoospermia J:77673
Leydig cell hyperplasia J:77673
retinal degeneration J:77673
retinal outer nuclear layer degeneration J:77673
retinal photoreceptor degeneration J:77673
Clcn2tm1Tjj/Clcn2tm1Tjj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal blood-brain barrier function J:122365
abnormal brain internal capsule morphology J:122365
abnormal brain morphology J:122365
abnormal brainstem morphology J:122365
abnormal cerebellum morphology J:122365
abnormal corpus callosum morphology J:122365
abnormal eye physiology J:68137
abnormal glial cell physiology J:210308
abnormal male germ cell morphology J:68137
abnormal microglial cell physiology J:122365
abnormal myelin sheath morphology J:122365, J:210308
abnormal nerve conduction J:122365
abnormal oligodendrocyte physiology J:210308
abnormal photoreceptor outer segment morphology J:68137
abnormal retinal outer nuclear layer morphology J:68137
abnormal seminiferous tubule morphology J:68137
abnormal Sertoli cell development J:68137
abnormal Sertoli cell morphology J:68137
abnormal spermatocyte morphology J:68137
abnormal spinal cord morphology J:122365
abnormal testis development J:68137
azoospermia J:68137
normal behavior/neurological phenotype J:68137, J:122365
brain vacuoles J:122365, J:210308
disorganized photoreceptor inner segment J:68137
disorganized photoreceptor outer segment J:68137
normal endocrine/exocrine gland phenotype J:68137
normal homeostasis/metabolism phenotype J:68137
Leydig cell hyperplasia J:68137
male infertility J:68137
normal nervous system phenotype J:122365
retinal degeneration J:68137
seminiferous tubule degeneration J:68137
small testis J:68137
Clcn2tm2.1Tjj/Clcn2tm2.1Tjj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal nervous system phenotype J:210308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory