Ptpn12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptpn12
protein tyrosine phosphatase, non-receptor type 12
MGI:104673

23 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12⁺ C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp	abnormal embryo size	J:211773
Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp	abnormal embryo size	J:211773
	abnormal pericardium morphology	J:211773
	edema	J:211773
	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Ptpn12^tm1Mtr/Ptpn12^tm1Mtr involves: 129S4/SvJae * BALB/c	abnormal embryo development	J:119668
	abnormal heart development	J:119668
	abnormal liver development	J:119668
	abnormal rostral-caudal body axis extension	J:119668
	abnormal septum transversum morphology	J:119668
	abnormal somite development	J:119668
	abnormal vascular branching morphogenesis	J:119668
	abnormal vitelline vasculature morphology	J:119668
	decreased vascular endothelial cell number	J:119668
	embryonic growth retardation	J:119668
	embryonic lethality during organogenesis, complete penetrance	J:119668
	failure of initiation of embryo turning	J:119668
	kinked neural tube	J:119668
	neural tube degeneration	J:119668
Ptpn12^tm1Vei/Ptpn12^tm1Vei Tg(Cd4-cre)1Cwi/0 B6.Cg-Tg(Cd4-cre)1Cwi Ptpn12^tm1Vei	abnormal cytokine secretion	J:163910
	abnormal T cell physiology	J:163910
	decreased T cell proliferation	J:163910
Ptpn12^tm1Vei/Ptpn12^tm1Vei Tg(Lck-cre)1Cwi/0 B6.Cg-Ptpn12^tm1Vei Tg(Lck-cre)1Cwi	decreased susceptibility to experimental autoimmune encephalomyelitis	J:163910

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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