Pml Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pml
promyelocytic leukemia
MGI:104662

17 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pml^tm1.1Ews/Pml^tm1.1Ews FVB.129P2-Pml^tm1.1Ews	abnormal double-strand DNA break repair	J:262172
	abnormal PML bodies	J:262172
	elevated level of mitotic sister chromatid exchange	J:262172
	increased cellular sensitivity to ionizing radiation	J:262172
	increased hematopoietic stem cell number	J:262172
	normal neoplasm	J:262172
Pml^tm1.1Ews/Pml^tm1.1Ews involves: 129 * 129P2/OlaHsd	increased B cell derived lymphoma incidence	J:262172
Pml^tm1.1Ews/Pml^tm1.1Ews involves: 129 * 129P2/OlaHsd	increased T cell derived lymphoma incidence	J:262172
Pml^tm1Ppp/Pml^tm1Ppp FVB.129S7-Pml^tm1Ppp	abnormal double-strand DNA break repair	J:262172
Pml^tm1Ppp/Pml^tm1Ppp FVB.129S7-Pml^tm1Ppp	increased hematopoietic stem cell number	J:262172
Pml^tm1Ppp/Pml^tm1Ppp involves: 129S7/SvEvBrd	abnormal cell physiology	J:46381
	abnormal immune system cell morphology	J:46381
	abnormal myelopoiesis	J:46381
	decreased granulocyte number	J:46381
	decreased leukocyte cell number	J:46381
	increased fibroblast proliferation	J:46381
	increased lymphoma incidence	J:46381
	increased susceptibility to bacterial infection	J:46381
	increased tumor incidence	J:46381

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23