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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mpz
myelin protein zero
MGI:103177
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccl2tm1Rol/Ccl2+
Mpztm1Msch/Mpz+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal macrophage derived foam cell morphology J:133028
decreased macrophage cell number J:133028
demyelination J:133028
neuron degeneration J:133028
Ccl2tm1Rol/Ccl2tm1Rol
Mpztm1Msch/Mpz+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal cytokine level J:133028
decreased macrophage cell number J:133028
demyelination J:133028
increased macrophage cell number J:133028
neuron degeneration J:133028
Csf1op/Csf1op
Mpztm1Msch/Mpz+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal myelination J:67581
normal immune system phenotype J:67581
Ddit3tm1Dron/Ddit3tm1Dron
Mpztm3.1Wra/Mpztm3.1Wra
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N 		decreased myelin sheath thickness J:241742
decreased nerve conduction velocity J:241742
dysmyelination J:241742
impaired coordination J:241742
Mpztm1Msch/Mpz+
Rag1tm1Mom/Rag1tm1Mom
B6.129S7-Mpztm1Msch Rag1tm1Mom 		abnormal myelin sheath morphology J:59319
abnormal myelination J:59319
abnormal nerve conduction J:59319
abnormal neuron morphology J:59319
absent CD4-positive, alpha-beta T cells J:59319
absent CD8-positive, alpha-beta T cells J:59319
increased Schwann cell number J:59319
Mpztm1Msch/Mpz+
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal myelin sheath morphology J:59319
abnormal nerve conduction J:59319
abnormal nervous system physiology J:59319
abnormal neuron morphology J:59319
decreased nerve conduction velocity J:59319
decreased T cell number J:59319
increased Schwann cell number J:59319
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory