Dck Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dck
deoxycytidine kinase
MGI:102726

33 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dck^m1Btlr/Dck⁺ C57BL/6J-Dck^m1Btlr	decreased B cell number	J:236696
Dck^m1Btlr/Dck⁺ C57BL/6J-Dck^m1Btlr	impaired hematopoiesis	J:236696
Dck^m1Btlr/Dck^m1Btlr C57BL/6J-Dck^m1Btlr	decreased B cell number	J:236696
	decreased CD4-positive, alpha-beta T cell number	J:236696
	decreased IgG level	J:236696
	decreased response to antigen	J:236696
	impaired hematopoiesis	J:236696
	increased CD8-positive, alpha-beta T cell number	J:236696
	increased IgE level	J:236696
	increased macrophage cell number	J:236696
Dck^memi/Dck^memi C57BL/6J-Dck^memi	abnormal myeloid leukocyte morphology	J:184080
	abnormal response to infection	J:184080
	abnormal T cell differentiation	J:184080
	decreased B cell number	J:184080
	decreased CD4-positive, alpha-beta T cell number	J:184080
	enlarged spleen	J:184080
	increased effector memory CD4-positive, alpha-beta T cell number	J:184080
	increased effector memory CD8-positive, alpha-beta T cell number	J:184080
	increased erythroid progenitor cell number	J:184080
	increased T cell apoptosis	J:184080
	increased T cell proliferation	J:184080
	small thymus	J:184080
	thymus hypoplasia	J:184080
Dck^tm1.1Radu/Dck^tm1.1Radu involves: 129S4/SvJae * BALB/cJ * C57BL/6 * C57BL/6J	abnormal double-negative T cell morphology	J:158373
	abnormal peripheral lymph node morphology	J:158373
	abnormal spleen morphology	J:158373
	abnormal T cell differentiation	J:158373
	abnormal thymus morphology	J:158373
	absent spleen white pulp	J:158373
	decreased B cell number	J:158373
	decreased double-positive T cell number	J:158373
	decreased pre-B cell number	J:158373
	decreased T cell number	J:158373
	extramedullary hematopoiesis	J:158373
	increased double-negative T cell number	J:158373
	increased pro-B cell number	J:158373
	increased spleen weight	J:158373
	reticulocytosis	J:158373
	thymus hypoplasia	J:158373
Dck^tm1.2Radu/Dck^tm1.2Radu involves: 129S4/SvJae * C57BL/6 * C57BL/6N * SJL	no abnormal phenotype detected	J:101977

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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