Dcktm1.1Radu
Targeted Allele Detail
|
Symbol: |
Dcktm1.1Radu |
Name: |
deoxycytidine kinase; targeted mutation 1.1, Caius G Radu |
MGI ID: |
MGI:4440453 |
Gene: |
Dck Location: Chr5:88912872-88931136 bp, + strand Genetic Position: Chr5, 43.96 cM, cytoband E2
|
Alliance: |
Dcktm1.1Radu page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:158373
|
Parent Cell Line: |
LW1 (ES Cell)
|
Strain of Origin: |
129S4/SvJae
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Exon 3 was floxed and an FRT flanked neo cassette was inserted within intron 3 by homologous recombination. Exon 3 is deleted by cre mediated recombination which eliminated the catalytic domain and also caused a frameshift mutation and early termination of the protein. Loss of function was confirmed by in vitro kinase assay as well as PET and CT imaging with labeled probes.
(J:158373)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Dck Mutation: |
20 strains or lines available
|
|
Original: |
J:158373 Toy G, et al., Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5551-6 |
All: |
2 reference(s) |
|