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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
MGI:101931
21 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd
Tg(Ins2-cre)25Mgn/0
B6.Cg-Slc1a2tm1.1Ncd Tg(Ins2-cre)25Mgn 		no abnormal phenotype detected J:207177
Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd
Tg(Nes-cre)1Kln/0
B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln 		decreased survivor rate J:207177
hyperactivity J:207177
premature death J:207177
seizures J:207177
slow postnatal weight gain J:207177
Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd
Tg(Pdx1-cre)1Heed/0
involves: 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:207177
Slc1a2tm1.1Pros/Slc1a2tm1.1Pros
Tg(GFAP-cre/ERT2)13Kdmc/0
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 		abnormal brain wave pattern J:221590
normal behavior/neurological phenotype J:221590
normal nervous system phenotype J:221590
premature death J:221590
seizures J:221590
slow postnatal weight gain J:221590
Slc1a2tm1.1Pros/Slc1a2tm1.1Pros
Tg(Syn1-cre)671Jxm/0
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 		abnormal synaptic physiology J:221590
normal behavior/neurological phenotype J:221590
normal growth/size/body region phenotype J:221590
normal mortality/aging J:221590
Slc1a2tm1Kta/Slc1a2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell physiology J:144898
Slc1a2tm1Kta/Slc1a2tm1Kta
B6.129P2-Slc1a2tm1Kta 		postnatal lethality, complete penetrance J:124191
Slc1a2tm1Kta/Slc1a2tm1Kta
involves: 129P2/OlaHsd * C57BL/6 		abnormal hippocampus CA1 region morphology J:40984
abnormal telencephalon morphology J:40984
cerebral edema J:40984
convulsive seizures J:40984
hippocampus pyramidal cell degeneration J:84859
increased susceptibility to pharmacologically induced seizures J:40984
postnatal growth retardation J:40984
premature death J:40984
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory